§ 556.113 - Ceftiofur.

§ 556.113 Ceftiofur.

(a) Acceptable daily intake and acceptable single-acute reference dose intake -

(1) Acceptable daily intake (ADI). The ADI for total residues residue of ceftiofur is 30 micrograms per kilogram µg/kg of body weight per day.

(2) Acceptable single-Acute reference dose intake (ASDIARfD). The ASDI ARfD for total residues residue of ceftiofur is 0.830 milligrams per kilogram mg/kg of body weight. The ASDI is the amount of total residues of ceftiofur that may safely be consumed in a single meal. The ASDI is used to derive the tolerance for residues of desfuroylceftiofur at the injection site.

(b) Tolerances -

(1) Poultry, and sheep

.

A tolerance for residues of ceftiofur in edible tissue is not required. (2) Swine.

The tolerances for desfuroylceftiofur (marker residue) are:

(1) Cattle.

(i) Kidney (target tissue)

.

: 0.

25 parts per million (

4 ppm

)

.

(ii) Liver

. 3

: 2 ppm.

(iii) Muscle

. 2

: 1 ppm.

(iv) Milk: 0.1 ppm.

(

3(

2)

Cattle. The tolerances for desfuroylceftiofur (marker residue) are:

Chickens and turkeys. Edible tissues (excluding eggs): Not required.

(3) Goats.

(i) Kidney (target tissue). 0.4 : 8 ppm.

(ii) Liver.: 2 ppm.

(iii) Muscle.: 1 ppm.

(iv) Milk.: 0.1 ppm.

[63 FR 53579, Oct. 6, 1998, as amended at 68 FR 60296, Oct. 22, 2003; 69 FR 43892, July 23, 2004; 71 FR 39546, July 13, 2006]

(4) Sheep. Edible tissues (excluding milk): Not required.

(5) Swine.

(i) Kidney (target tissue): 0.25 ppm.

(ii) Liver: 3 ppm.

(iii) Muscle: 2 ppm.

(c) Related conditions of use. See §§ 522.313a, 522.313b, 522.313c, and 526.313 of this chapter.