94-537. National Toxicology Program; Availability of Technical Report on Toxicology and Carcinogenesis Studies of p-Nitrophenol

[Federal Register Volume 59, Number 7 (Tuesday, January 11, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-537]


[[Page Unknown]]

[Federal Register: January 11, 1994]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES
 

National Toxicology Program; Availability of Technical Report on 
Toxicology and Carcinogenesis Studies of p-Nitrophenol

    The HHS' National Toxicology Program announces the availability of 
the NTP Technical Report on the toxicology and carcinogenesis studies 
of p-Nitrophenol used in the production of acetaminophen, methyl and 
ethyl parathion insecticides, fungicides, and dyestuffs.
    Eighteen-month toxicology and carcinogenesis studies were conducted 
by applying p-Nitrophenol in acetone to the intrascapular skin of 
groups of 60 Swiss-Webster mice of each sex. Doses of 0, 40, 80, or 160 
mg/kg p-Nitrophenol were administered to mice 3 days per week for 78 
weeks.
    Under the conditions of these 18-month dermal studies there was no 
evidence of carcinogenic activity\1\ in male or female Swiss-Webster 
mice receiving 40, 80, or 160 mg/kg p-Nitrophenol.
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    \1\The NTP uses five categories of evidence of carcinogenic 
activity observed in each animal study: Two categories for positive 
results (``clear evidence'' and ``some evidence''), one category for 
uncertain findings (``equivocal evidence''), one category for no 
observable effect (``no evidence''), and one category for studies 
that cannot be evaluated because of major flaws (``inadequate 
study'').
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    Questions or comments about the Technical Report should be directed 
to Central Data Management at P.O. Box 12233, Research Triangle Park, 
NC 27709 or telephone [phone].
    Copies of Toxicology and Carcinogenesis Studies of p-Nitrophenol 
(CAS No. 100-02-7) in Swiss-Webster Mice (Dermal Studies) (TR-417) are 
available without charge from Central Data Management, NIEHS, MD AO-01, 
P.O. Box. 12233, Research Triangle Park, NC 27709; telephone (919) 541-
3419.

    Dated: January 3, 1994.
Kenneth Olden,
Director, National Toxicology Program.
[FR Doc. 94-537 Filed 1-10-94; 8:45 am]
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