[Federal Register Volume 63, Number 206 (Monday, October 26, 1998)]
[Notices]
[Pages 57132-57133]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-28606]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program (NTP) Board of Scientific Counselors'
Meeting; Review of Nominations for Listing in or Delisting From the 9th
Report on Carcinogens
Pursuant to Public Law 92-463, notice is hereby given of the next
meeting of the NTP Board of Scientific Counselors' Report on
Carcinogens (RoC) Subcommittee to be held on December 2 & 3, 1998, in
the Conference Center, Building 101, South Campus, National Institute
of Environmental Health Sciences (NIEHS), 111 Alexander Drive, Research
Triangle Park, North Carolina. The meeting will begin at 8:30 a.m. both
days and is open to the public. The agenda topics are the peer review
of substances, mixtures, or exposure circumstances nominated for
listing in or delisting from the 9th Report on Carcinogens, and the
provision of the opportunity for public input.
Background
The process for preparation of the Report on Carcinogens (RoC) has
three levels of scientific peer review. Central to the evaluations of
the review groups is the use of revised criteria, for inclusion in or
removal of substances from the Report, which were approved by the
Secretary, Department of Health and Human Services (DHHS), in September
1996. The major change in the RoC which occurred as a result of the
criteria revision was to include consideration of all relevant
information, including mechanistic data, in the decision to list in or
delist from future volumes. To broaden the scope of scientific review
and broaden input to preparation of the Report, a new standing
subcommittee of the NTP Board of Scientific Counselors was established
in 1996. The meeting on December 2 & 3 will be the third meeting at
which the RoC Subcommittee has conducted public review of nominations.
The current review process for review of petitions considered by the
NTP for listing in or delisting from the RoC begins with initial
scientific review by the NIEHS/NTP Report on Carcinogens Review
Committee (RG1). The RG1 is comprised of NIEHS/NTP staff scientists.
The second scientific review phase is done by the NTP Executive
Committee's Working Group for the Report on Carcinogens (RG2). RG2 is
comprised of representatives of the Federal health research and
regulatory agencies on the
[[Page 57133]]
Executive Committee. The third level of review is the external public
review by the RoC Subcommittee and includes time for public comments.
The independent recommendations of the three scientific peer review
groups and all public comments are presented to the NTP Executive
Committee for review and comment. The Director, NTP, receives the four
independent recommendations and makes NTP recommendations regarding
listing or delisting to the Secretary, DHHS.
Agenda
Tentatively scheduled to be peer reviewed on December 2 & 3 are 11
nominations. An alphabetical listing of the nominations with supporting
information follows this announcement. The table notes the tentative
order of presentation and review in the right hand column, and gives
primary uses or exposures and the category for which they were
originally nominated. Draft background documents on each of the
nominations will be provided to Board Subcommittee reviewers around
November 1. Paper copies of draft background documents can be obtained,
as available, from: the Board Executive Secretary, Dr. Larry G. Hart,
P.O. Box 12233, Research Triangle Park, NC 27709 (telephone 919/541-
3971; FAX 919/541-0295; emailhart@niehs.nih.gov.)
Public Input Encouraged
The entire meeting is open to the public and time will be provided
for public comment on each of the nominations being reviewed. In order
to facilitate planning for the meeting, persons wanting to make a
formal presentation regarding a particular nomination must notify the
Executive Secretary by telephone, by FAX, by mail, or by email no later
than November 30, 1998, and, if possible, provide a written copy of
their statement in advance of the meeting. Written statements should
supplement and may expand on the oral presentation, or may be submitted
in lieu of an oral presentation, and should be received by November 30
so copies can be made for distribution to Subcommittee members and
staff and made available for the public. All attempts will be made to
send statements received by November 24 to Subcommittee members in
advance of the meeting. Oral presentations must be limited to no more
than five minutes.
Upon request, the Executive Secretary, Dr. Larry G. Hart, at the
address given above, will furnish the agenda and a roster of
Subcommittee members prior to the meeting. Summary minutes subsequent
to the meeting will be available upon request.
Attachment.
Dated: October 16, 1998.
Kenneth Olden,
Director, National Toxicology Program.
Summary Data for Nominations Tentatively Scheduled for Review at the Meeting of the NTP Board of Scientific
Counselors' Report on Carcinogens Subcommittee December 2 & 3, 1998
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Tentative
Nomination/CAS No. Primary uses or exposures To be reviewed for review
order
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Alcoholic Beverages.................... Consumption of alcoholic Listing in the 9th Report 3
beverages.
Boot and Shoe Manufacture and Repair... Workers in the boot and shoe Listing in the 9th Report 11
manufacture and repair
industry.
Diesel Particulates.................... Diesel engine exhaust.......... Listing in the 9th Report 7
Environmental Tobacco Smoke............ ``Passive'' inhalation of Listing in the 9th Report 4
tobacco smoke from
environmental sources.
Ethyl Acrylate/140-88-5................ Monomer used to produce Delisting from the Report 9
polymers and copolymers for on Carcinogens.
use in latex paints, textiles,
etc.
Ethylene Oxide/75-21-8................. Industrial chemical used as an Change current listing to 6
intermediate in the the Known to be a Human
manufacture of other Carcinogen category.
chemicals; e.g., ethylene
glycol and is widely used in
the health care industry as a
sterilant.
Isoprene/78-79-5....................... The monomeric unit of natural Listing in the 9th Report 2
rubber and naturally occurring
terpenes and steroids and
widely used in the production
of isoprene-butadiene
copolymers.
Methyl-t-Butyl Ether/1634-04-4......... Used as an additive in unleaded Listing in the 9th Report 8
gasoline in amounts up to 11%.
Nickel Compounds....................... Many industrial and commercial Change current listing to 10
applications. the Known to be a Human
Carcinogen category.
Silica, Crystalline/7631-86-9.......... Exposure from mining and Change current listing to 5
quarrying of coal and other the Known to be a Human
minerals, stone cutting, Carcinogen category.
production of glass and
ceramics and in occupations
such as sandblasting,
polishing and grinding.
2,3,7,8-Tetrachloro-dibenzo-p-dioxin Not used commercially, used Change current listing to 1
(TCDD)/1746-01-6. only as a research chemical. the Known to be a Human
Potential exposure from Carcinogen category.
municipal incinerators, dump
sites and contaminated soil.
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[FR Doc. 98-28606 Filed 10-23-98; 8:45 am]
BILLING CODE 4140-01-M
