[Federal Register Volume 59, Number 210 (Tuesday, November 1, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-26973]
[[Page Unknown]]
[Federal Register: November 1, 1994]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Toxicology Program; National Toxicology Program (NTP)
Board of Scientific Counselors' Meeting; Review of Draft NTP Technical
Reports
Pursuant to Public Law 92-463, notice is hereby given of the next
meeting of the NTP Board of Scientific Counselors' Technical Reports
Review Subcommittee on November 29, 1994, in the Conference Center,
Building 101, South Campus, National Institute of Environmental Health
Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North
Carolina. The meeting will begin at 8:30 a.m. and is open to the
public. The primary agenda topic is the peer review of draft Technical
Reports of long-term toxicology and carcinogenesis studies from the
National Toxicology Program. Additionally, the draft Technical Report
of the short-term toxicity study on 1-nitropyrene will be reviewed.
This is the first NTP short-term report where the conclusion has been
drawn that the chemical is a likely carcinogen in the absence of
neoplasms in an NTP study.
Tentatively scheduled to be peer reviewed on November 29 are draft
Technical Reports of six two-year studies, listed alphabetically, along
with supporting information in the attached table. Similar information
is given for the short-term report on 1-nitropyrene. All studies were
done using Fischer 344 rats and B6C3F1 mice, while one two-year
study also employed Sencar mice. The order of review is given in the
far right column of the table. Copies of the draft Reports may be
obtained, as available, from: Central Data Management, MD A0-01, P.O.
Box 12233, Research Triangle Park, NC 27709 (919/541-3419).
Persons wanting to make a formal presentation regarding a
particular Technical Report must notify the Executive Secretary by
telephone, by FAX, or by mail no later than November 22, 1994, and
provide a written copy in advance of the meeting so copies can be made
and distributed to all Subcommittee members and staff and made
available at the meeting for attendees. Oral presentations should
supplement and not just repeat the written statement. Presentations
should be limited to no more than five minutes.
The program would welcome receiving toxicology and carcinogenesis
information from completed, ongoing, or planned studies by others, as
well as current production data, human exposure information, and use
patterns on any of the chemicals listed in this announcement. Please
contact Central Data Management at the address given above, and they
will relay the information to the appropriate staff scientist.
The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233,
Research Triangle Park, North Carolina 27709 (telephone 919/541-3491;
FAX 919/541-2260) will furnish a roster of Subcommittee members prior
to the meeting. Summary minutes subsequent to the meeting will be
available upon request.
Attachment
Dated: October 26, 1994.
Richard A. Griesemer,
Deputy Director, National Toxicology Program.
Summary Data for Technical Reports Scheduled for Review at the Meeting of the NTP Board of Scientific
Counselors' Technical Reports Review Subcommittee
[November 29, 1994]
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Project leader/
Chemical/CAS No. technical report Primary uses Route/exposure levels Study laboratory Review
No. order
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LONG-TERM STUDIES
----------------------------------------------------------------------------------------------------------------
2,2-Bis Dr. J. Dunnick, Flame retardant for Dosed-Feed (NIH-07): Southern 5
(bromomethyl)-1, 919-541-4811; TR- epoxy, polyester, and R: 0, 2500, 5000, or Research
3-Propanediol; 452. urethane forms. 10000 PPM; 70/group Institute.
3296-90-0. Chemical intermediate. M: 0, 312, 625, or
1250 PPM; 60/group.
Isobutyl nitrite; Dr. K. Abdo, 919- Industrial Inhalation (air): IIT Research 1
542-56-3. 541-7819; TR-448. intermediate in R&M: 0, 37, 75, or Institute.
chemical synthesis. 150 PPM.
(TDB).
Nickel (II) Dr. J. Dunnick, Chemical intermediate Inhalation (air): R: Lovelace Inhal 3
oxide; 1313-99-1. 919-541-4811; TR- for stainless and 0, .62, 1.25, or 2.5 Tox Res Inst
451. alloy steels. M: 0, 1.25, 2.5, or (DOE).
Catalysts. Electrical 5.0 mg/m3; 50/group.
devices. Thermister
material.
Nickel sulfate Dr. J. Dunnick, Nickel plating. Inhalation (air): R: Lovelace Inhal 4
hexahydrate, 919-541-4811, TR- Blackening zinc and 0, 0.125, 0.25, or Tox Res Inst
10101-97-0. 454. brass. Mordant in 0.5 M: 0, .25, .5, (DOE).
dyeing. or 1.0 mg/m3; 50/
group.
Nickel Dr. J. Dunnick, Major component in Inhalation (air): R: Lovelace Inhal 2
subsulfide; 919-541-4811; TR- nickel refinery flue 0, 0.075, or 0.15 M: Tox Res Inst
12035-72-2. 453. dust. Not used 0, 0.6, or 1.2 mg/ (DOE).
commercially in U.S. m3; 50/group.
Triethanolamine; Dr. J. Bucher, Intermediate in manuf. Topical (acetone): Battelle 6
102-71-6. 919-541-4532; TR- surfactants, textile MR: 0, 32, 63, or Columbus
449. specialties, waxes, 125; FR: 0, 63, 125 Laboratory.
polishes, herbicides, or 250; MM: 0, 200,
petroleum 630, or 2000; FM: 0.
demulsifiers, toilet
goods.
Triethanolamine; Dr. J. Bucher, Intermediate in manuf. Topical (acetone): Battelle 6
102-71-6. 919-541-4532; TR- surfactants, textile MR: 0, 32, 63, or Columbus
449. specialties, waxes, 125; FR: 0, 63, 125, Laboratory.
polishes, herbicides, or 250; MM: 0, 200,
petroleum 630, or 2000; FM: 0,
demulsifiers, toilet 100, 300, or 1000 mg/
goods, cement kg; 60/group.
additives, cutting
oils, in making
mineral and veg. oil
emulsions, solvent,
pharmaceutic aid
(alkalizer) (Merck
1989).
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SHORT-TERM TOXICITY STUDY
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1-Nitropyrene; Dr. P. Chan, 919- Byproduct of Inhalation (air): R: Battelle 7
5522-43-0. 541-7561; TOX-34. combustion primary 0, 0.5, 2.0, 8.0, Northwest
nitrated PAH emitted 20.0, or 50.0 mg/m3 Laboratory.
in diesel engine 12/s/group (core); 5/
exhaust. s/group for lung
burden.
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R=Rats.
M=Mice.
[FR Doc. 94-26973 Filed 10-31-94; 8:45 am]
BILLING CODE 4140-01-M
