[Federal Register Volume 61, Number 223 (Monday, November 18, 1996)]
[Notices]
[Pages 58698-58699]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-29465]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institute of Environmental Health Sciences; National
Toxicology Program (NTP) Board of Scientific Counselors' Meeting;
Review of Draft NTP Technical Reports
Pursuant to Public Law 92-463, notice is hereby given of the next
meeting of the NTP Board of Scientific Counselors' Technical Reports
Review Subcommittee on December 11 and 12, 1996, in the Conference
Center, Building 101, South Campus, National Institute of Environmental
Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park,
North Carolina. The meeting will begin at 8:30 a.m. both days and is
open to the public. The agenda topic is the peer review of draft
Technical Reports of long-term toxicology and carcinogenesis studies
from the National Toxicology Program.
Tentatively scheduled to be peer reviewed on December 11-12 are
draft Technical Reports of 10 two-year studies, listed alphabetically,
along with supporting information in the attached table. All studies
were done using Fischer 344 rats and B6C3F1 mice. The order of
review is given in the far right column of the table. Copies of the
draft Reports may be obtained, as available, from: Central Data
Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709
(919/541-3419).
Persons wanting to make a formal presentation regarding a
particular Technical Report must notify the Executive Secretary by
telephone, by FAX, or by mail no later than December 6, 1996, and
provide a written copy in advance of the meeting so copies can be made
and distributed to all Subcommittee members and staff and make
available at the meeting for attendees. Written statements should
supplement and may expand on the oral presentation. Oral presentations
should be limited to no more than five minutes.
The program would welcome receiving toxicology and carcinogenesis
information from completed, ongoing, or planned studies by others, as
well as current production data, human exposure information, and use
patterns for any of the chemicals listed in this announcement. Please
contact Central Data Management at the address given above, and they
will relay the information to the appropriate staff scientist.
The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233,
Research Triangle Park, North Carolina 27709 (telephone 919/541-3971;
FAX 919/541-0295) will furnish agenda and a roster of Subcommittee
members prior to the meeting. Summary minutes subsequent to the meeting
will be available upon request to Central Data Management.
Dated: November 11, 1996.
Kenneth Olden,
Director, National Toxicology Program.
Summary Data for Technical Reports Tentatively Scheduled for Review at the Meeting of the Board of Scientific
Counselor's Technical Reports Review Subcommittee, December 11-12, 1996
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Technical report Route exposure Review
Chemical CAS No. No. Primary uses levels order
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3'-AZIDO-3'-deoxythymidine (AZT) TR-469 Pyrimidine Gavage 5% 2
30516-87-1 and. nucleoside analog Methylcellulose):
with antiviral Mice only: 0, 30,
activity used in 60, OR 120 MG/KG;
the treatment of 50/SEX.
AIDS (Merck 1989).
INTERFERON AD+ AZT (AIDS ................... Used in the Subcutaneous Inj.+
INITIATIVE). experimental Gavage (.5%
treatment of AIDS. Methylcellulose):
DUAL ROUTES WITH
BOTH COMPOUNDS:
AZT: 0, 30, 60, OR
120 (GAV) MG/KG;
IFN: 500 OR 5000
UNITS 3X/WEEK.
CHLOROPRENE 126-99-8.............. TR-467 Monomer for neoprene Inhalation (Air): 4
elastomers; Rats & Mice: 0,
industrial rubber 12.8, 32.0, OR 80.0
products; component PPM; 50/SEX/SPECIES/
of laboratory GROUP.
adhesives in food
packaging.
[[Page 58699]]
COBALT SULFATE HEPTAHYDRATE 10026- TR-471 Drying agent for Inhalation (Air): 3
24-1. varnishes and inks; Rats & Mice; 0,
component of 0.3, 1.0, OR 3.0 MG/
electroplating M3; 50/SEX/SPECIES/
solutions. GROUP.
ETHLYBENZENE 100-41-4............. TR-466 Manufacture of Inhalation (Air) 6
synthetic rubber. Rats & Mice: 0, 75,
Solvent. Fuel 250, 750 PPM (50/
additive. Chemical SEX/SPECIES/GROUP).
intermediate.
ISOBUTYRALDEHYDE 78-84-2.......... TR-472 Synthesis of Inhalation (Air) 10
pantothenic acid, Rats & Mice: 0,
cellulose esters, 500, 1000, OR 2000
perfumes, flavors, PPM (50/SEX/SPECIES/
and gasoline GROUP).
additives. Chemical
intermediate.
OXAZEPAM 604-75-1................. TR-468 Tranquilizer........ Dosed-Feed (NIH-07): 1
Rats only: 0, 625,
1250, 2500, 5000,
OR 10000 PPM; 50/
SEX/GROUP.
POLYVINYL ALCOHOL 9002-89-5....... TR-474 PVA film for Intravaginal 8
intravaginal (Deionized Water):
administration of Mice only: 25% PVA,
spermicides. VEHICLE, UNTREATED;
Textile warp sizing 100/GROUP.
and finishing,
adhesives.
Pesticides. Pigment
in TV picture tubes.
PRIMIDONE (PRIMACLONE) 125-33-7... TR-476 Prophylactic Dosed-Feed (NIH-07 9
management of Mice: 0, 0.03,
partial grand mal 0.06, OR 0.13% Rats
and psychomotor & Mice: 0, 0.06,
seizures that are 0.13, OR 0.25% (50/
refractory to other SEX/SPECIES).
antiepileptic drugs.
TETRAHYDROFURAN 109-99-9.......... TR-475 Reaction medium for Inhalation (Air) 7
grignard and metal Rats & Mice: 0,
hydride reactions. 200, 600, OR 1800
Packaging PPM (50/SEX/SPECIES/
fabrication. GROUP).
Solvent for resins
and plastics.
Chemical
intermediate.
THEOPHYLLINE 58-55-9.............. TR-473 Diuretic, cardiac Gavage (Corn Oil): 5
stimulant, smooth Rats: 0, 7.5, 25,
muscle relaxant, OR 75 MG/KG; 50/
antiasthmatic, GROUP Female Mice:
occurs naturally in 0, 7.5, 25, OR 75
tea (Merck 1989). MG/KG; 50/GROUP
Male Mice: 0, 15,
50, OR 150 MG/KG;
50/GROUP.
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[FR Doc. 96-29465 Filed 11-15-96; 8:45 am]
BILLING CODE 4140-01-M
