[Federal Register Volume 61, Number 214 (Monday, November 4, 1996)]
[Notices]
[Page 56680]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-28242]
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ENVIRONMENTAL PROTECTION AGENCY
[FRL-5646-8]
PCBs: Cancer Dose-Response Assessment and Application to
Environmental Mixtures
AGENCY: Environmental Protection Agency.
ACTION: Notice of availability of final document.
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SUMMARY: This notice announces the availability of a final report
titled, PCBs: Cancer Dose-Response Assessment and Application to
Environmental Mixtures (EPA/600/P-96/001F). The National Center for
Environmental Assessment (NCEA) of the Office of Research and
Development developed this report.
ADDRESSES: The document will be available on the Internet at http://
www.epa.gov/ORD/WebPubs or for purchase from the National Technical
Information Service, 5285 Port Royal Road, Springfield, VA 22161;
telephone 703-487-4650; facsimile 703-321-8547. The NTIS order number
is PB97-104616. Copies will be available for inspection at the U.S.
Environmental Protection Agency (EPA) headquarters and regional
libraries and through the U.S. Government Depository Library program.
The EPA Headquarters Library is located at 401 M Street, S.W.,
Washington, DC; the library is open Monday through Friday between 10:00
a.m. and 2:00 p.m., except for Federal holidays.
FOR FURTHER INFORMATION CONTACT: Dr. Jim Cogliano, National Center for
Environmental Assessment/Washington Office (8602), U.S. Environmental
Protection Agency, 401 M Street, S.W., Washington, DC 20460. Telephone:
202-260-3830; facsimile: 202-260-3803; E-mail:
cogliano.jim@epamail.epa.gov.
SUPPLEMENTARY INFORMATION: The report updates the cancer dose-response
assessment for polychlorinated biphenyls (PCBs) and shows how
information on toxicity, disposition, and environmental processes can
be considered together to evaluate health risks from PCB mixtures in
the environment. Processes that chemically change PCB mixtures after
release into the environment need to be considered in assessing the
mixtures. Thus, guidance is given on applying a range of dose-response
parameters to different exposure routes, partial lifetime exposure, and
mixtures of varying composition. Intended to be brief, the document
focuses on analysis and interpretation rather than a compilation of
study results. The PCB report was reviewed at a public, external peer
review workshop in May 1996. The review panel included experts on the
carcinogenicity of PCBs from the private sector, academia, states, and
other federal health agencies. This final report has been reviewed and
approved by EPA's consensus review panel for inclusion on EPA's on-line
Integrated Risk Information System (IRIS). A revised cancer information
summary file, reflecting the quantitative and qualitative information
in the final PCB report, has been loaded onto IRIS.
Dated: October 22, 1996.
Robert J. Huggett,
Assistant Administrator for Research and Development.
[FR Doc. 96-28242 Filed 11-1-96; 8:45 am]
BILLING CODE 6560-50-P
