[Federal Register Volume 63, Number 239 (Monday, December 14, 1998)]
[Notices]
[Pages 68783-68785]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-33090]
[[Page 68783]]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program; Call for Public Comments on 11
Agents, Substances, Mixtures and Exposure Circumstances Proposed for
Listing in or Delisting from the Report on Carcinogens, Ninth Edition
Background
The National Toxicology Program (NTP) solicits final public
comments on additional agents, substances, mixtures and exposure
circumstances for listing in or delisting from the Report on
Carcinogens, Ninth Edition. This Report is a Congressionally mandated
listing of known human carcinogens and reasonably anticipated human
carcinogens and the Secretary, Department of Health and Human Services
(HHS) delegates its preparation to the National Toxicology Program.
Section 301(b)(4) of the Public Health Service Act, as amended,
provides that the Secretary, (HHS), shall publish a report which
contains a list of all substances (1) which either are known to be
human carcinogens or may reasonably be anticipated to be human
carcinogens; and (2) to which a significant number of persons residing
in the United States (US) are exposed. The law also states that the
reports should provide available information on the nature of
exposures, the estimated number of persons exposed and the extent to
which the implementation of Federal regulations decrease the risk to
public health from exposure to these chemicals.
In 1998, 11 substances or exposure circumstances were reviewed for
listing in or removal from the Ninth Report. This review included two
Federal and one non-government, scientific peer reviews and public
comment and review. The three scientific review committee evaluated all
available data relevant to the criteria for inclusion or removal of
candidate substances or exposure circumstances in the Report. The
criteria used in the review process and the detailed description of the
review procedures, including the steps in the current formal review
process, can be obtained by contacting: Dr. C.W. Jameson, National
Toxicology Program, Report on Carcinogens, 79 Alexander Drive, Room
3217, P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919)
541-4096, fax: (919) 541-2242, email: jameson@niehs.nih.gov. This
information is also available on the NTP Home Page web site at http://
ntp-server.niehs.nih.gov/
Public Comment Requested
The NTP will be making a final recommendation in 1999 for the 11
substances or exposure circumstances reviewed in 1998, for either
listing in, delisting from, or changing the current listing from
reasonably anticipated to be a human carcinogen to the known to be a
human carcinogen category in the Ninth Report. These nominated
substances or exposure circumstances are provided in the following
table with their Chemical Abstracts Services (CAS) Registry numbers
(where available) and the recommendations from the three scientific
peer reviews of the nominations.
Background documents provided to the review committees and the
interested public are available upon request. The NTP will review the
recommendations of each of the review committees and consider the
public comments received throughout the process in making decisions
regarding the NTP recommendations to the Secretary, DHHS, for listing
or removal of the nominated substances and exposure circumstances in
the Ninth Edition of the Report on Carcinogens. The NTP solicits final
public comment to supplement any previously submitted comments or to
provide comments for the first time on any substance or exposure
circumstances in the following table. Comments will be accepted for a
period of 60 days from the date of the publication of this announcement
in the Federal Register. Comments or questions should be directed to
Dr. C.W. Jameson at the address listed above.
Attachment
Dated: December 4, 1998.
Kenneth Olden,
Director, National Toxicology Program.
Summary of RG1,\1\ RG2 \2\ and NTP Board Subcommittee \3\ Recommendations for the Agents, Substances, Mixtures
or Exposure Circumstances Reviewed in 1998 for Listing in or Delisting from the Report on Carcinogens,\4\ 9th
Edition
----------------------------------------------------------------------------------------------------------------
NTP board
Nomination/CAS No. Primary uses or RG1 action RG2 action subcommittee
exposures action
----------------------------------------------------------------------------------------------------------------
Alcoholic Beverages............. Consumption of RG1 recommended (6 RG2 unanimously The Subcommittee
alcoholic yes votes to 1 no recommended (7 recommended (9
beverages. vote) listing as yes votes to 0 no yes votes to 3 no
known to be a votes) listing as votes with 1
human carcinogen. known to be a abstention)
human carcinogen. listing as known
to be a human
carcinogen.
Boot and Shoe Manufacture and Workers in the RG1 recommended (5 RG2 recommended (6 The Subcommittee
Repair. boot and shoe yes votes to 1 no yes votes to 1 no unanimously
manufacture and vote) that Boot vote) that Boot recommended (10
repair industry. and Shoe and Shoe yes votes to 0 no
Manufacture and Manufacture and votes) to defer
Repair in the Repair in the action on this
United States be United States be nomination
included in the included in the because of the
RoC as having RoC as having lack of exposure
been reviewed but been reviewed but assessment
not formally not formally information.
listed, due to listed, due to
inadequate data. inadequate data.
Diesel Exhaust Particulates..... Diesel engine RG1 defeated a RG2 recommended (6 The Subcommittee
exhaust. motion to list as yes votes to 1 no recommended (9
reasonably vote) to list as yes votes to 0 no
anticipated to be reasonably votes with 3
a human anticipated to be abstentions) to
carcinogen (4 yes a human list as
votes to 5 no carcinogen. reasonably
votes). RG1 anticipated to be
recommended (5 a human
yes votes to 4 no carcinogen.
votes) to list as
known to be a
human carcinogen.
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Environmental Tobacco Smoke..... ``Passive'' RG1 recommended (7 RG2 recommended (5 The Subcommittee
inhalation of yes votes to 0 no yes votes to 2 no unanimously
tobacco smoke vote with 1 votes) to list as recommended (13
from abstention) to known to be a yes votes to 0 no
environmental list as known to human carcinogen. votes) listing as
sources. be a human known to be a
carcinogen. human carcinogen.
Ethyl Acrylate/140-88-5......... Monomer used to RG1 recommended (7 RG2 recommended (6 The Subcommittee
produce polymers yes votes to 2 no yes votes to 1 no recommended (8
and copolymers votes) to delist vote) to delist yes votes to 2 no
for use in latex from RoC. from RoC. votes with 2
paints, textiles, abstentions) to
etc. delist from the
RoC.
Ethylene Oxide/75-21-8.......... Industrial RG1 recommended (6 RG2 unanimously The Subcommittee
chemical used as yes votes to 1 no recommended (7 recommended (6
an intermediate vote) to upgrade yeas votes to 0 yes votes to 5 no
in the to a known human no votes) to votes with 1
manufacture of carcinogen. upgrade to a abstention) to
other chemicals; known human upgrade to a
e.g., ethylene carcinogen. known human
glycol and is carcinogen.
widely used in
the health care
industry as a
sterilant.
Isoprene/78-79-5................ The monomeric unit RG1 unanimously RG2 recommended (6 The Subcommittee
of natural rubber recommended (6 yes votes to 0 no unanimously
and naturally yes votes to 0 no votes with 1 recommended (13
occurring votes) to list as abstention) to yes votes to 0 no
terpenes and reasonably list as votes) to list as
steroids and anticipated to be reasonably reasonably
widely used in a human anticipated to be anticipated to be
the production of carcinogen. a human a human
isoprene- carcinogen. carcinogen.
butadiene
copolymers.
Methyl-t-Butyl Ether/1634-04-4.. Used as an RG1 recommended (4 RG2 voted against The Subcommittee
additive in yes votes to 3 no motion to list as voted against
unleaded gasoline votes) to list as reasonably motion to list as
in amounts up to reasonably anticipated to be reasonably
11%. anticipated to be a human anticipated to be
a human carcinogen (3 yes a human
carcinogen. votes to 4 no carcinogen (5 yes
votes). votes to 6 no
votes with 1
abstention).
Nickel Compounds................ Many industrial RG1 unanimously RG2 recommended (4 The Subcommittee
and commercial recommended (7 yes votes to 3 no unanimously
applications. yes votes to 0 no votes with 1 recommended (12
votes) to upgrade abstention to yes votes to 0 no
to a known human upgrade to a votes) to upgrade
carcinogen. known human to a known human
carcinogen. carcinogen.
Silica, Crystalline (Respirable Exposure from RG1 unanimously RG2 recommended (5 The subcommittee
Size)/7631-86-9. mining and recommended (9 yes votes to 2 no recommended (11
quarrying of coal yes votes to 0 no votes) to upgrade yes votes to 1 no
and other votes) to upgrade to a known human vote) to upgrade
minerals, stone to a known human carcinogen. to a known human
cutting, carcinogen. carcinogen.
production of
glass and
ceramics and in
occupations such
as sandblasting,
polishing and
grinding.
2,3,7,8-TETRACHLORODIBENZ O-P- Not used RG1 unanimously RG2 unanimously The Subcommittee
DIOXIN (TCDD)/1746-01-6. commercially, recommended (10 recommended (8 voted against
found as a yes votes to 0 no yes votes to 0 no motion to upgrade
contaminant in votes) to upgrade votes) to upgrade current listing
the production of to a known human to a known human to known human
some pesticides carcinogen. carcinogen. carcinogen. (5
and other yes votes to 7 no
commercial votes with 1
products. abstention).
----------------------------------------------------------------------------------------------------------------
\1\ The NIEHS Review Committee for the Report on Carcinogens (RG1).
\2\ The NTP Executive Committee* Interagency Working Group for the Report on Carcinogens (RG2).
*Agencies represented on the NTP Executive Committee include: Agency for Toxic Substances and Disease Registry
(ATSDR), Consumer Product Safety Commission (CPSC), Environmental Protection Agency (EPA), Food and Drug
Administration (FDA), National Center for Toxicological Research (NCTR), National Institute for Occupational
Safety and Health (NIOSH), Occupational Safety and Health Administration (OSHA), Department of Health and
Human Services (DHHS), National Institutes of Health (NIH), National Cancer Institute (NCI), National Library
of Medicine (NLM), and National Institute of Environmental Health Sciences/NTP (NIEHS/NTP).
\3\ The NTP Board of Scientific Counselor Report on Carcinogens Subcommittee (the External Peer Review Group).
\4\ RoC-Report on Carcinogens.
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[FR Doc. 98-33090 Filed 12-11-98; 8:45 am]
BILLING CODE 4140-01-M
