[Federal Register Volume 61, Number 232 (Monday, December 2, 1996)]
[Notices]
[Page 63853]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-30538]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, DHH.
ACTION: Notice.
-----------------------------------------------------------------------
The inventions listed below are owned by agencies of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for U.S. companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804 (telephone 301/496-7057; fax 301/402-0220). A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
Image Registration Using Voxel Gradients With an Iterative Registration
Process
J Ostuni (LDRR)
Serial No. 60/016,429 filed 29 Apr 96
Licensing Contact: John Fahner-Vihtelic, 301/496-7735 ext. 285
To date, it has been difficult to combine or compare images which
represent a similar scene using different and unrelated intensities,
for example, two magnetic resonance volumes taken with different
sequences. The current invention represents a means by which this
difficulty may be overcome, and embodies an algorithm which allows for
the registration or the ``matching up'' of multiple three-dimensional
images. Specifically, the algorithm is based upon finding the
correspondence of closest gradient voxels, where a gradient voxel is
any voxel containing a high 3D intensity gradient. Typically, gradient
voxels represent areas of change within the image. This algorithm can
successfully perform registrations under conditions of unrelated voxel
intensity, significant object motion and/or significant amounts of
missing data. The invention, therefore, represents a powerful new tool
for users of a variety of three-dimensional systems. (portfolio:
Devices/Instrumentation--Other)
Compositions for the Prevention or Retardation of Cataracts
JS Zigler Jr., P Russell, S Tumminia, C Qin, CM Krishna (NEI)
Serial No. 60/010,637 filed 26 Jan 96
Licensing Contract: J. Peter Kim, 301/496-7056, ext. 264
Oxidative stress is becoming recognized a major problem, and free
radicals and activated oxygen species are recognized as agents of
tissue damage associated with a number of conditions. Aging-related
cataract is a disease of multifactorial origin involving many of the
same processes which characterize the process of aging in other
tissues. It appears that once cataractogenesis has begun, the process
of cataract development may proceed via one or more common pathways or
processes. The subject invention focuses on intervening at the level of
these common pathways in hopes of stopping or slowing the progression
of the disease process. The present invention provides methods and
compositions for the prevention and treatment of cataract formation
which comprise a nitroxide free radical compound or its hydroxylamine
and a thiol reducing agent. (portfolio: Ophthalmology--Therapeutics,
chemical)
Molecular Cloning and Characterization of a Differentiation Antigen,
CAK1, Present on Mesothelium, Mesotheliomas and Ovarian Cancers
I Pastan, K Chang (NCI)
Serial No. 60/010,166 filed 05 Jan 96
Licensing Contact: Larry Tiffany, 301/496-7056 ext 206
CAK1, or ``mesothelin'', is an antigen present on the cell surface
in mesothelium and on many mesotheliomas and ovarian cancers. While the
role of this differentiation antigens has not yet been determined, it
is postulated that it may be implicated in adhesion and in the
dissemination of mesotheliomas and of ovarian cancers. CAK1, therefore,
is a potential target for monoclonal antibodies to be used in the
diagnosis and treatment of these cancers. The gene for CAK1 has been
cloned and sequenced, as embodied in the current invention. The
invention, therefore, should provide a valuable research tool for use
in the development of diagnostics and/or therapeutic agents toward
mesotheliomas and ovarian cancers. (portfolio: Cancer--Research
Materials, DNA based)
Method of Mobilizing Pluripotential Hematopoietic Stem Cells With
IL-7
RH Wiltrout, F Ruscetti, K Grzegorzewski, J Keller, KL Komschlies-
McConville (NCI)
Serial No. 08/341,399 filed 16 Nov 94
Licensing Contact: Jaconda Wagner, 301/496-7735 ext 284
This invention provides a method of increasing numbers of
hematopietic stem cells in a subject by administering interleukin-7 to
the subject. Hematopoietic stem cells are distinguishable from
hematopoietic progenitor cells in that the stem cells are pluripotent
and not yet committed to myeloid or lymphoid lineages. After treatment,
a population of leukocytes enriched for hematopoietic stem cells may be
isolated from the subject's peripheral blood. Such a population of
leukocytes enriched from hematopoietic stem cells may be transferred
into a recipient in order to enhance the repopulation of the
recipient's hematopoietic and immune cells. In addition, the method
provides for improved engraftment of a bone marrow transplant in a
recipient following transplantation or irradiation. A Notice of
Allowance has recently been issued for this patent application.
(portfolio: Internal Medicine--Therapeutics; Cancer--Therapeutics;
biological response modifiers, growth factors)
Dated: November 20, 1996.
Barbara M. McGarey,
Deputy Director, Office of Technology Transfer.
[FR Doc. 96-30538 Filed 11-29-96; 8:45 am]
BILLING CODE 4140-01-M
