97-3528. Government-Owned Inventions; Availability for Licensing  

  • [Federal Register Volume 62, Number 30 (Thursday, February 13, 1997)]
    [Notices]
    [Pages 6789-6790]
    From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
    [FR Doc No: 97-3528]
    
    
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    DEPARTMENT OF HEALTH AND HUMAN SERVICES
    
    Government-Owned Inventions; Availability for Licensing
    
    AGENCY: National Institutes of Health, HHS.
    
    ACTION: Notice.
    
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        The invention referenced below is owned by an agency of the U.S. 
    Government and is available for licensing in the U.S. in accordance 
    with 35 U.S.C. 207 to achieve expeditious commercialization of results 
    of federally-funded research and development. Foreign patent 
    applications are filed on selected inventions to extend market coverage 
    for U.S. companies and may also be available for licensing.
    
    ADDRESSES: Licensing information and a copy of the U.S. patent 
    application referenced below may be obtained by contacting Stephen 
    Finley, Ph.D., at the Office of Technology Transfer, National 
    Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
    Maryland 20852-3804; Telephone: 301/496-7735 ext 215; Fax: 301/402-
    0220. A signed Confidential Disclosure Agreement will be required to 
    receive a copy of the patent application.
    
    Allelic Variation of the Serotonin 5HT7 Receptor
    
    U Pesonen, M Koulu, M Linnoila, D Goldman, and M Virkkunen (NIAAA)
    Serial No. 08/745,269 filed 08 Nov 96 (claiming priority date of 
    November 09, 1995
    
        The 5HT7 serotonin receptor is structurally distinct from 
    known serotonin receptors and exhibits a high affinity for serotonin 
    and several antipsychotic and antidepressant drugs. The 
    neurotransmitter serotonin has a variety of functions in the CNS, and 
    disruption of serotonergic systems may be a factor in a number of 
    clinical disorders or conditions including schizophrenia, depression, 
    obsessive compulsive disorder, anxiety, sleep disorders, migraine 
    headaches, and pain. This invention identifies a rare nonconservative 
    mutation of the human 5HT7 serotonin receptor. The mutation from 
    Pro279, a common amino acid found in the helical turns of 
    proteins, to Leu279 in the third cytoplasmic loop may alter the 
    secondary and tertiary structure of the receptor and create changes in 
    binding affinities. The 5HT7 Leu279 receptor may prove valuable 
    for studying the function of this neurotransmitter in the CNS and make 
    it possible to find biochemical and genetic variables that predict 
    vulnerability to psychiatric disorders, including antisocial 
    personality, and therefore predict these behaviors and also facilitate 
    implementation of preventative and therapeutic measures. The receptor 
    may also be used in medication development and screening for ligands 
    that may bind to the receptor,as well as in receptor inhibition 
    studies.
    
    (Portfolios: Central Nervous System--Research Materials receptors 
    and cell lines; Central Nervous System--Research Materials, cDNA 
    clones and probes)
    
    
    [[Page 6790]]
    
    
        Dated: February 4, 1997.
    Barbara M. McGarey,
    Deputy Director, Office of Technology Transfer.
    [FR Doc. 97-3528 Filed 2-12-97; 8:45 am]
    BILLING CODE 4140-01-M
    
    
    

Document Information

Published:
02/13/1997
Department:
Health and Human Services Department
Entry Type:
Notice
Action:
Notice.
Document Number:
97-3528
Pages:
6789-6790 (2 pages)
PDF File:
97-3528.pdf