[Federal Register Volume 63, Number 22 (Tuesday, February 3, 1998)]
[Notices]
[Pages 5565-5567]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-2563]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program; Call for Public Comments;
Substances, Mixtures and Exposure Circumstances Proposed for Listing in
or Delisting (Removing) From the Report on Carcinogens, Ninth Edition
Background
The National Toxicology Program (NTP) announces its intent to
review additional substances, mixtures and exposure circumstances for
possible listing in or delisting (removing) from the Report on
Carcinogens, Ninth Edition. This Report (previously known as the Annual
Report on Carcinogens) is a Congressionally-mandated listing of known
human carcinogens and
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reasonably anticipated human carcinogens and its preparation is
delegated to the National Toxicology Program by the Secretary,
Department of Health and Human Services (DHHS). Section 301(b)(4) of
the Public Health Service Act, as amended, provides that the Secretary,
(DHHS), shall publish a report which contains a list of all substances
(1) which either are known to be human carcinogen or may be reasonably
anticipated to be a human carcinogen, and (2) to which a significant
number of persons residing in the United States (US) are exposed. The
law also states that the reports should provide available information
on the nature of exposures, the estimated number of persons exposed and
the extent to which the implementation of Federal regulations decreases
the risk to public health from exposure to these chemicals.
The review of the substances, mixtures or exposure circumstances
for listing in, changing the current listing from reasonably
anticipated to be a human carcinogen to known to be a human carcinogen
or delisting from the Ninth Report will involve a multiphased, peer
review process involving two Federal scientific review groups and one
non-government, scientific peer review body (a subcommittee on the NTP
Board of Scientific Counselors) which will meet in an open, public
meeting that will provide for public comments. All available data
relevant to the criteria for inclusion or removal of candidate agents,
substances, mixtures or exposure circumstances in the Report will be
evaluated by the three scientific review committees. The criteria to be
used in the review process and the detailed description of the review
procedures, including the steps in the formal review process, can be
obtained by contacting: Dr. C. W. Jameson, National Toxicology Program,
Report on Carcinogens, MD EC-14, P.O. Box 12233, Research Triangle
Park, NC 27709; phone: (919) 541-5096, fax: (919) 541-2242, email:
jameson@niehs.nih.gov.
Public Comment Requested
The NTP will be considering 11 substances, mixtures and exposure
circumstances in 1998, for either listing in or delisting (removing)
from, or changing the current listing from reasonably anticipated to be
a human carcinogen to the known to be a human carcinogen category in
the Ninth Report. These substances, mixtures, or exposure circumstances
are provided in the following table with their chemical Abstracts
Services (CAS) Registry numbers (where available) and pending review
action. The NTP solicits public input on these 11 substances, mixtures
and exposure circumstances and asks for relevant information anyone may
have on carcinogenesis from completed, ongoing, or planned studies by
others, as well as current production data, use patterns, and human
exposure information for any of the substances, mixtures or exposure
circumstances listed in this announcement. Comments concerning the
review of these substances, mixtures or exposure circumstances for
listing in or delisting from the Ninth Report on Carcinogens will be
accepted for a period of 45 days from the date of the publication of
this announcement in the Federal Register. Comments or questions should
be directed to Dr. C. W. Jameson at the address listed above.
Public Nominations for Delisting or Listing Encouraged
The NTP solicits and encourages the broadest participation from
interested individuals or parties in nominating agents, substances, or
mixtures for listing in or delisting from the Ninth and future Reports
on Carcinogens. Petitions should contain a rationale for listing or
delisting. Appropriate background information and relevant data (e.g.
Journal articles, NTP Technical Reports, IARC listings, exposure
surveys, release inventories, etc.) which support a petition should be
provided or referenced when possible.
A detailed description of listing/delisting procedures, including
the steps in the formal review process, can be obtained by contacting
Dr. Jameson at the address listed above.
Dated: January 26, 1998.
Kenneth Olden,
Director, National Toxicology Program.
Summary for Agents, Substances, Mixtures or Exposure Circumstances To Be Reviewed in 1998, for Consideration of
Listing in or Delisting From the Ninth Report on Carcinogens
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Substance or exposure circumstance/
CAS Number Primary uses or exposures To be reviewed for
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Alcoholic Beverages................ Consumption of alcoholic beverages............. Listing in the 9th Report.
Boot and Shoe Manufacture and Workers in the boot and shoe manufacture and Listing in the 9th Report.
Repair. repair industry.
Diesel Particulates................ Diesel engine exhaust.......................... Listing in the 9th Report.
Environmental Tobacco Smoke........ ``Passive'' inhalation of tobacco smoke from Listing in the 9th Report.
environmental sources.
Ethyl Acrylate/140-88-5............ Monomer used to produce polymers and copolymers Delisting from the Report
for use in latex paints, textiles, etc. on Carcinogens.
Ethylene Oxide/75-2-8.............. Industrial chemical used as an intermediate in Change current listing to
the manufacture of other chemicals; e.g., the Known to be a Human
ethylene glycol and is widely used in the Carcinogen category.
health care industry as a sterilant.
Isoprene/78-79-5................... The monomeric unit of natural rubber and Listing in the 9th Report.
naturally occurring terpenes and steroids and
widely used in the production of isoprene-
butadiene copolymers.
Methyl-t-Butyl Ether/1634-04-4..... Used as an additive in unleaded gasoline in Listing in the 9th Report.
amounts up to 11%.
Nickel and Nickel Compounds/7440-02- Many industrial and commercial applications.... Change current listing to
0. the Known to be a Human
Carcinogen category.
Nickel Refining.................... Workers in the nickel refining industry........ Listing in the 9th Report.
Silica, Crystalline/7631-86-9...... Exposure from mining and quarrying of coal and Change current listing to
other minerals, stone cutting, production of the Known to be a Human
glass and ceramics and in occupations such as Carcinogen category.
sandblasting, polishing and grinding.
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[FR Doc. 98-2563 Filed 2-2-98; 8:45 am]
BILLING CODE 4140-01-M
