[Federal Register Volume 64, Number 49 (Monday, March 15, 1999)]
[Notices]
[Page 12816]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 99-6206]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, DHHS.
ACTION: Notice.
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SUMMARY: The inventions listed below are owned by agencies of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to Girish C.
Barua, Ph.D. at the Office of Technology Transfer, National Institutes
of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland
20852-3804; telephone: 301/496-7057 ext. 263; fax: 301/402-0220; e-
mail: gb18tnih.gov. A signed Confidential Disclosure Agreement will be
required to receive copies of the patent applications.
Mixing Arrangement and Method
Lesley Pesnicak (NIAID)
Serial No. 08/823,417 filed 25 Mar 97; U.S. Patent 5,810,773 issued 22
Sep 98
An arrangement for sterilely mixing two viscous fluids together. It
consists of a base with removable stops to accommodate two syringes
(different sizes can be used) and a 3-way stopcock. Two commercially
available syringes are connected to a 3-way stopcock and fitted onto
the base such that the flanges of the syringes are up against stops
connected to the base and the 3 way stopcock is fitted into stops also
connected to the base in such a manner that syringes and stopcock are
unable to pull apart when the desired fluids are forced through the
stopcock from one syringe to another. In this manner two fluids can be
easily mixed without the loss for material which might result from the
syringes popping off the stopcock and the ability to provide complete
sterility. This device is especially good for emulsification of
peptides.
Isolation of Amplified Genes Via cDNA Subtractive Hybridization
Bertrand C. Liang (NCI)
Serial No. 08/700, 763 filed 09 Aug 96; U.S. Patent 5,827,658 issued 27
Oct 98
A method of analyzing an amplified gene, including determining its
copy number involves subtractive hybridization of cDNA libraries, one
from the tissue of interest and the other containing biotinylated cDNA
from normal tissue, where the annealed cDNA is removed by means of
magnetic beads coated with streptevidin or avidin. The cDNA isolated
after subtractive hybridization represents amplified DNA, and it is
analyzed to determine what gene(s) were amplified. Furthermore, the
copy number of the gene(s) can be estimated. The copy number thus
determined can be correlated to the severity of a pathogenic state, to
the prognosis or to treatment efficacy.
Method of Identifying and Using Drugs With Selective Effect Against
Cancer Cells
George F. Vande Woude, Anne P. Monks, Han-Mo Koo (NCI) Serial No. 08/
260,515 filed 15 Jun 94; U.S. Patent 5,645,983 issued 08 Jul 97
The invention covers a method of identifying drugs which
selectively inhibit the growth of particular cancer cells. This is
accomplished by contacting cancer cells, which differ as to the
presence of a particular DNA sequence with a drug and measuring the
effect of the drug on growth of the cells. A determination is then made
as to whether there is a correlation between the growth rate and
presence or absence of the DNA sequence.
The invention may potentially be applied in research and
development of cancer therapeutics, or as a diagnostic. It may provide
the ability to design combinations of drugs for cancer treatment.
Dated: March 5, 1999.
Jack Spiegel,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer.
[FR Doc. 99-6206 Filed 3-12-99; 8:45 am]
BILLING CODE 4140-01-M
