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59 FR (04/11/1994) » 94-8607. National Institute of Allergy and Infectious Diseases; Opportunity for a Cooperative Research and Development Agreement (CRADA) for the Design and Screening of Protease-Resistant Synthetic Peptides With the Anti-Tumor and Immunodulating ...
94-8607. National Institute of Allergy and Infectious Diseases; Opportunity for a Cooperative Research and Development Agreement (CRADA) for the Design and Screening of Protease-Resistant Synthetic Peptides With the Anti-Tumor and Immunodulating ...
[Federal Register Volume 59, Number 69 (Monday, April 11, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-8607]
[[Page Unknown]]
[Federal Register: April 11, 1994]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and Infectious Diseases;
Opportunity for a Cooperative Research and Development Agreement
(CRADA) for the Design and Screening of Protease-Resistant Synthetic
Peptides With the Anti-Tumor and Immunodulating Activity
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
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SUMMARY: The National Institute of Allergy and Infectious Diseases
(NIAID) of the National Institutes of Health is seeking capability
statements from parties interested in entering into a Cooperative
Research and Development Agreement (CRADA) on a project to design and
screen protease-resistant synthetic peptides with anti-tumor and
immunomodulating activity. This project is with the Laboratory of
Immunology (LI). The proposed project is based on NIAID's
identification and on biochemical characterization of functionally
important individual proteins/enzymes or surface receptors which have
been implicated in the lymphocyte activation/differentiation or as
having anti-tumor activity. These proteins include:
(1) The novel set of ectoproteins (enyzmes), which are located on
the cell surface and utilize extracellular ATP [ectoprotein
phosphatases, ectoprotein kinases and ectoATPases as well as the
purinergic receptors (ATP-receptor)]; and
(2) Intracellular catalytic subunit of the cAMP-dependent protein
kinase. The goal is to develop specific reagents (protease-resistant
synthetic peptides and monoclonal antibody) which will either mimic the
cytotoxic properties of ATP or will inhibit extracellular ATP-utilizing
ecto-enyzmes. Our main efforts now are to obtain the detailed
information (cDNA cloning, antibody production, analysis of
transfectants) about these enzymes and receptors. The availability of
such structural information is required for the development of new
pharmacologically active drugs. Capability statements should include;
(1) technical expertise of proposed Collaborator Principal Investigator
and laboratory group in molecular cloning and antibody production, (2)
ability of Collaborator to prepare or order highly purified synthetic
peptides, and (3) ability to adequately contribute funding to support
required research.
ADDRESSES: Capability statements shall be submitted to: Dr. Harold T.
Safferstein, Technology Transfer Branch, National Institute of Allergy
and Infectious Diseases, National Institutes of Health, Building 31,
room 7A32, 9000 Rockville Pike, Bethesda, Maryland 20892; Tel: 301-496-
2644.
DATES: May 11, 1994.
Dated: March 31, 1994.
Donald P. Christoferson,
Acting Director, Office of Technology Transfer.
[FR Doc. 94-8607 Filed 4-8-94; 8:45 am]
BILLING CODE 4140-01-M
Document Information
- Published:
- 04/11/1994
- Department:
- National Institutes of Health
- Entry Type:
- Uncategorized Document
- Action:
- Notice.
- Document Number:
- 94-8607
- Dates:
- May 11, 1994.
- Pages:
- 0-0 (1 pages)
- Docket Numbers:
- Federal Register: April 11, 1994