94-8607. National Institute of Allergy and Infectious Diseases; Opportunity for a Cooperative Research and Development Agreement (CRADA) for the Design and Screening of Protease-Resistant Synthetic Peptides With the Anti-Tumor and Immunodulating ...  

  • [Federal Register Volume 59, Number 69 (Monday, April 11, 1994)]
    [Unknown Section]
    [Page 0]
    From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
    [FR Doc No: 94-8607]
    
    
    [[Page Unknown]]
    
    [Federal Register: April 11, 1994]
    
    
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    DEPARTMENT OF HEALTH AND HUMAN SERVICES
    National Institutes of Health
    
     
    
    National Institute of Allergy and Infectious Diseases; 
    Opportunity for a Cooperative Research and Development Agreement 
    (CRADA) for the Design and Screening of Protease-Resistant Synthetic 
    Peptides With the Anti-Tumor and Immunodulating Activity
    
    AGENCY: National Institutes of Health, Public Health Service, HHS.
    
    ACTION: Notice.
    
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    SUMMARY: The National Institute of Allergy and Infectious Diseases 
    (NIAID) of the National Institutes of Health is seeking capability 
    statements from parties interested in entering into a Cooperative 
    Research and Development Agreement (CRADA) on a project to design and 
    screen protease-resistant synthetic peptides with anti-tumor and 
    immunomodulating activity. This project is with the Laboratory of 
    Immunology (LI). The proposed project is based on NIAID's 
    identification and on biochemical characterization of functionally 
    important individual proteins/enzymes or surface receptors which have 
    been implicated in the lymphocyte activation/differentiation or as 
    having anti-tumor activity. These proteins include:
        (1) The novel set of ectoproteins (enyzmes), which are located on 
    the cell surface and utilize extracellular ATP [ectoprotein 
    phosphatases, ectoprotein kinases and ectoATPases as well as the 
    purinergic receptors (ATP-receptor)]; and
        (2) Intracellular catalytic subunit of the cAMP-dependent protein 
    kinase. The goal is to develop specific reagents (protease-resistant 
    synthetic peptides and monoclonal antibody) which will either mimic the 
    cytotoxic properties of ATP or will inhibit extracellular ATP-utilizing 
    ecto-enyzmes. Our main efforts now are to obtain the detailed 
    information (cDNA cloning, antibody production, analysis of 
    transfectants) about these enzymes and receptors. The availability of 
    such structural information is required for the development of new 
    pharmacologically active drugs. Capability statements should include; 
    (1) technical expertise of proposed Collaborator Principal Investigator 
    and laboratory group in molecular cloning and antibody production, (2) 
    ability of Collaborator to prepare or order highly purified synthetic 
    peptides, and (3) ability to adequately contribute funding to support 
    required research.
    
    ADDRESSES: Capability statements shall be submitted to: Dr. Harold T. 
    Safferstein, Technology Transfer Branch, National Institute of Allergy 
    and Infectious Diseases, National Institutes of Health, Building 31, 
    room 7A32, 9000 Rockville Pike, Bethesda, Maryland 20892; Tel: 301-496-
    2644.
    
    DATES: May 11, 1994.
    
        Dated: March 31, 1994.
    Donald P. Christoferson,
    Acting Director, Office of Technology Transfer.
    [FR Doc. 94-8607 Filed 4-8-94; 8:45 am]
    BILLING CODE 4140-01-M
    
    
    

Document Information

Published:
04/11/1994
Department:
National Institutes of Health
Entry Type:
Uncategorized Document
Action:
Notice.
Document Number:
94-8607
Dates:
May 11, 1994.
Pages:
0-0 (1 pages)
Docket Numbers:
Federal Register: April 11, 1994