[Federal Register Volume 63, Number 93 (Thursday, May 14, 1998)]
[Notices]
[Pages 26818-26820]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-12779]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program; Availability of the Report on
Carcinogens, Eighth Edition
Background
The National Toxicology Program (NTP) announces the availability of
the Report on Carcinogens, Eighth Edition.
[[Page 26819]]
The Report on Carcinogens (RoC) is a Congressionally-mandated
listing of known human carcinogens and reasonably anticipated human
carcinogens and its preparation is delegated to the National Toxicology
Program by the Secretary, Department of Health and Human Services
(HHS). Section 301(b)(4) of the Public Health Service Act, as amended,
provides that the Secretary, (HHS), shall publish a report which
contains a list of all substances (1) which either are known to be
human carcinogens or may reasonably be anticipated to be human
carcinogens; and (2) to which a significant number of persons residing
in the United States (US) are exposed. The law also states that the
reports should provide available information on the nature of
exposures, the estimated number of persons exposed and the extent to
which the implementation of Federal regulations decreases the risk to
public health from exposure to these chemicals.
The new entries for the 8th RoC have undergone a multiphased peer
review process involving two Federal scientific review groups and one
non-government, scientific peer review body (a subcommittee of the NTP
Board of Scientific Counselors) which met in an open, public meeting
that included a public comment session. All data relevant to the
criteria for inclusion of candidate agents, substances or mixtures in
the RoC have been evaluated by the three scientific review committees.
In the 8th RoC, the NTP is adding 14 agents, substances or mixtures
to the existing list. In addition, thiotepa, which is currently listed
in previous Reports on Carcinogens as reasonably anticipated to be a
human carcinogen is moved to the known human carcinogen list. These
agents, substances or mixtures are provided in the following table with
their Chemical Abstracts Services (CAS) Registry numbers and listing.
Hard copies of the 8th RoC, or the 8th RoC Summary (which contains
the same information that is in the full Report with the exception of
specific information on regulations promulgated by regulatory health
agencies) can be obtained by contacting the NIEHS Environmental Health
Information Service, ATTN: Order Processing, P.O. Box 12510, Research
Triangle Park, NC 27709-2510, fax number (919) 541-0763, email:
ehis@niehs.nih.gov. The 8th RoC Summary is also available on the
internet and can be accessed from the NIEHS Environmental Health
Information Service Home Page at: http:///ehis.niehs.nih.gov/ or from
the NTP Home Page at: http://ntp-server.niehs.nih.gov//.
Questions or comments concerning the 8th RoC should be directed to:
Dr. C.W. Jameson, National Toxicology Program, Report on Carcinogens,
MD EC-14, P.O. Box 12233, Research Triangle Park, NC 27709; phone:
(919) 541-4096, fax: (919) 541-2242, email: jameson@niehs.nih.gov.
Kenneth Olden,
Director, National Toxicology Program.
Summary for Agents, Substances or Mixtures Newly Listed in the Report on Carcinogens, Eighth Edition
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Chemical/CAS number Primary uses Newly listed as
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AZACITIDINE/320-67-2............... Used as a cytostatic agent in the treatment of Reasonably Anticipated to
acute leukemia. be a Human Carcinogen
p-CHLORO-o-TOLUIDINE and its HCl Used to produce azo dyes for cotton, silk Reasonably Anticipated to
salt/95-69-2. acetate and nylon and as intermediate in be a Human Carcinogen.
production of Pigment Red 7 and Pigment Yellow
49. Also an impurity in and a metabolite of
the pesticide chlordimeform.
CHLOROZOTOCIN/54749-90-5........... Used as a cytostatic agent in the treatment of Reasonably Anticipated to
cancers of the stomach, large intestine be a Human Carcinogen.
pancreas and lung; melanoma; and multiple
myeloma.
CYCLOSPORIN/59865-13-3............. Used as an immunosuppressive agent in the Known to be a Human
prevention and treatment of graft-vs-host Carcinogen.
reactions in bone marrow transplantation and
for the prevention of rejection of kidney,
heart, and liver transplants.
DANTHRON/(1,8- Used as a laxative and as an intermediate in Reasonably Anticipated to
Dihydroxyanthraquinone) 117-10-2. the manufacture of dyes. be a Human Carcinogen
1,6-DINITROPYRENE/42397-64-8....... Not used commercially, detected in ambient Reasonably Anticipated to
atmospheric samples and as a constituent of be a Human Carcinogen
diesel exhaust.
1,8-DINITROPYRENE/42397-65-9....... Not used commercially, detected in ambient Reasonably Anticipated to
atmospheric samples and as a constituent of be a Human Carcinogen
diesel exhaust.
DISPERSE BLUE 1/(1,4,5,8- Used as an anthraquinone based dyestuff in hair Reasonably Anticipated to
Tetraaminoanthraquinone) 2475-45-8. color formulations and in coloring fabrics and be a Human Carcinogen
plastics.
FURAN/100-00-9..................... Used as an intermediate in the synthesis and Reasonably Anticipated to
production of other organic compounds. be a Human Carcinogen
O-NITROANISOLE/91-23-6............. Used a a precursor in the synthesis of o- Reasonably Anticipated to
anisidine which is used in the manufacture of be a Human Carcinogen.
over 100 azo dyes.
6-NITROCHRYSENE/7495-02-8.......... Not used commercially, detected in ambient Reasonably Anticipated to
atmospheric samples. be a Human Carcinogen.
1-NITROPYRENE/5522-43-0............ Not used commercially, detected in ambient Reasonably Anticipated to
atmospheric samples and as a constituent of be a Human Carcinogen.
diesel and gasoline engine exhaust.
4-NITROPYRENE/57835-92-4........... Not used commercially, detected in ambient Reasonably Anticipated to
atmospheric samples. be a Human Carcinogen.
THIOTEPA/52-24-4................... Used as a cytostatic agent in the treatment of Known to be a Human
lymphomas and a variety of solid tumors, such Carcinogen.
as breast and ovary. It has also been used at
high doses in combination chemotherapy with
cyclophosphamide in patients with refractory
malignancies treated with autologous bone
transplantation.
[[Page 26820]]
1,2,3-TRICHLOROPROPANE/96-18-4..... Used as a polymer crosslinking agent, paint and Reasonably Anticipated to
varnish remover, solvent and degreasing agent. be a Human Carcinogen.
It has been found as an impurity in certain
nematicides and soil fumigants and has been
detected in drinking and ground water in
various parts of the United States.
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[FR Doc. 98-12779 Filed 5-13-98; 8:45 am]
BILLING CODE 4140-01-M
