[Federal Register Volume 63, Number 105 (Tuesday, June 2, 1998)]
[Notices]
[Pages 30007-30008]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-14497]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Pubic Health Service, DHHS.
ACTION: Notice.
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SUMMARY: The inventions listed below are owned by agencies of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
Applicator System And Method Of Use
MJ Lenardo, G Fisher (NIAID)
Serial No. 09/005,475 Filed 12 Jan 98
Licensing Contact: John Fahner-Vihtelic, 301/496-7735 ext. 270.
The present application describes a novel microcentrifuge tube and
tube cap and research method, which allows for dispensing the contents
of a microcentrifuge tube without pipetting. The design eliminates
pipetting volume error and prevents the cross-contamination which can
be experienced in conventional pipetting. This invention is
particularly useful for such applications as loading tube contents into
an electrophoresis gel after a reaction such as PCR. Using the
disclosed apparatus and methods increases the speed of a variety of
routine procedures and prevents contamination of samples due to soiled
lab apparatus.
Linking Compounds Useful For Coupling Carbohydrates To Amine-
Containing Carriers
P Kova, J Zhang (NIDDK)
Serial No. 60/069,686 Field 12 Dec 97
Licensing Contact: Robert Benson, 301/496-7056 ext. 267.
This invention describes an inexpensive and easy method of linking
carbohydrates and carriers containing an amino group to form
neoglycoconjugates. The resulting neoglycoconjugates are useful as
vaccines (i.e., bacterial LPS or LOS-carrier protein conjugate
vaccines) or as biologically active chromatographic substrates (i.e.,
carbohydrates bound to aminopropyl glass). The method involves specific
linkers that are easily made from inexpensive commercially available
starting materials. The carbohydrates to be used in the method are
limited only by the ability to convert such carbohydrates into glycosyl
donors. Claimed are the linkers, conjugates made with the linkers and
intermediates, and methods of synthesizing the linkers and conjugates.
The invention is described in Tetrahedron letters 39, 1091-1094, 1998.
System And Method For Intelligent Quality Control Of A Process
JM DeLeo (CIT), AT Remaley (CC)
Serial No. 60/066,624 Filed 26 Nov 97
Licensing Contact: John Fahner-Vihtelic, 301/496-7735 ext. 270.
The present application is a methodology for monitoring the quality
control of a process on-line for the purpose of predicting and
preventing unusual/untoward events or failures in that process. Such
processes include (but are not limited to) acquisition of medical data
from laboratory instruments, assembly line manufacturing, and general
plant or factory operations. The methodology is based on a two-tiered
automated intelligent agent architecture. Intelligent agents in the
first tier are neural networks trained to detect specific errors for
specific process environment parameters. The single-agent second tier
is an expert system that integrates inputs from first tier agents to
derive corrective action decisions that are manually or automatically
executed in the process environment. Error prevalence and wrong-
decision cost information are factored into the action decision-making
process. For clinical laboratory instruments, the method monitors
patient laboratory data and provides significant improvement in quality
control at reduced cost compared to existing methods.
Identification Of The Human Pendred Syndrome Gene
E Green, et al. (NHGRI)
DHHS Reference No. E-004-98/0 Filed 28 Oct 97
Licensing Contact: Dennis Penn, 301/496-7065, ext. 211.
Pendred syndrome is a recessively inherited disorder which was
poorly understood until the discovery of the Pendred syndrome gene.
This syndrome, which is associated with congenital deafness and thyroid
goiter, may account for upwards of 10% of hereditary deafness. The gene
encodes for the protein pendrin which transports sulfate across cell
membranes. However, the gene, when mutated, is responsible for
producing defective pendrin and causing Pendred syndrome. Pendrin
therefore plays a key role in thyroid function and the development and
functioning of the auditory system. Learning how pendrin functions
could lead to a better understanding of thyroid function and the
development of the auditory system. Finally, the resulting knowledge
into the genetic basis of Pendred syndrome will allow for improved
diagnosis of syndrome-specific mutations in at-risk individuals. This
research has been published in Nature Genetics 1997 December;
17(4):411-22.
Local Magnetization Spoiling Using A Gradient Insert For Reducing
The Field Of View In Magnetic Resonance Imaging
DG Wiesler, H Wen, RS Balaban, SD Wolff (NHLBI)
Serial No. 60/043,292 Filed 11 Apr 97
Licensing Contact: John Fahner-Vihtelic, 301/496-7735, ext. 270.
The present invention provides a method and device for eliminating
alias artifacts encountered in MRI when the field of view is made
smaller than the subject being imaged. Significant
[[Page 30008]]
advantages accrue from reducing the field of view to a smaller region
of interest. These include reduced imaging time, increased spatial and
temporal resolution, and less susceptibility to motion artifacts. The
device operates by dephasing the magnetic resonance signal in regions
away from the region of interest by means of a gradient insert.
Nitrogen-Containing Cylohetero Cycloalkyl-Aminoaryl Derivatives For
CNS Disorders
BR DeCosta, et al. (NIDDK)
Serial No. 07/473,008 Filed 31 Jan 90 (U.S. Patent 5,130,330 Issued on
14 Jul 92); Serial No. 07/877,190 Filed 01 Jul 92 (U.S. Patent
5,739,158 Issued on 14 Apr 98); Serial No. 08/335,532 Filed 07 Nov 94
Licensing Contact: Charles Maynard, 301/496-7735, ext. 243.
This technology includes compositions for a novel family of
nitrogen containing cyclohetero cycloalkyl-aminoaryl compounds for use
in the field of clinical neurology. The intellectual property relates
specifically to a class of therapeutically useful compounds for the
treatment of central nervous system (CNS) disorders such as cerebral
ischemia, psychotic disorders and convulsions. These compounds are
particularly useful for treating neurotoxic injury which follow periods
of hypoxia, anoxia or ischemia associated with stroke, cardiac arrest
or perinatal asphyxia.
The novel semirigid derivatives (+)-cis-1-[2-phenyl-2-
bicyclo[3,1,0]hexyl]piperidine [(+)-8], its enantiomer (-)-8, and (+-)-
trans-1-[2-phenyl-2-bicylo [3,1,0]piperidine [(+/-)-9] are illustrative
examples of this family of compounds which may be used to treat CNS
disorders and diseases such as cerebral ischemia, psychotic disorders
and convulsions, as well as prevention of neurotoxic damage and
neurodegenerative disease via a unique receptor mechanism. This class
of compounds produce neuroprotective effects by a different mechanism
to phencyclidine and metaphit a non-competitive N-methyl-D-aspartic
acid antagonis.
Dated: May 21, 1998.
Jack Spiegel,
Director, Division of Technology, Development, and Transfer, Office of
Technology Transfer.
[FR Doc. 98-14497 Filed 6-1-98; 8:45 am]
BILLING CODE 4140-01-M
