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AGENCY:
National Institutes of Health, HHS.
ACTION:
Notice.
SUMMARY:
The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. to achieve expeditious commercialization of results of federally-funded research and development.
Start Further InfoFOR FURTHER INFORMATION CONTACT:
Licensing information may be obtained by emailing Michael Shmilovich, shmilovm@nih.gov, the indicated licensing contact at the National Heart, Lung, and Blood, Office of Technology Transfer and Development Office of Technology Transfer, 31 Center Drive Room 4A29, MSC2479, Bethesda, MD 20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure Agreement may be required to receive any unpublished information.
End Further Info End Preamble Start Supplemental InformationSUPPLEMENTARY INFORMATION:
Technology description follows.
Liposome Nanodecoys That Protect Against SARS-COV-2
Available for licensing and commercial development are patent rights covering a liposomal vesicle (a “nanodecoy”) with a lipid bilayer with one or more proteins recognized by a pathogen (e.g., SARS-CoV-2) and one or more cytokine receptors (such as IL-6; receptors: CD126, CD130; IL-1; receptors: CD121a, CD121b, IL-8; receptors: IL-8RB; IL-12; receptors: CD212; TNF-α; receptors: CD120a, CD120b; IFN-γ; receptors: CD119, IFN-α/β; receptors: CD118) and wherein the liposomal vesicle is non-replicating. Nanodecoys that display angiotensin-converting enzyme 2 (ACE2) and multiple cytokine receptors, are able to sequester SARS-CoV-2 and inhibit viral replication and infection, as well as to mitigate COVID-19-induced cytokine release syndrome (CRS) in susceptible cells.
Potential Commercial Applications:
- COVID-19
- SARS-CoV-2
- Cytokine release syndrome
○ immunosuppression
- Viral inhibition
○ Receptor binding competition
Development Stage:
- Preclinical
Inventors: Xiaoyuan (Shawn) Chen (NIBIB) and Lang Rao (NIBIB).
Intellectual Property: HHS Reference No. E-144-2020-0-US-01 “Engineered Cell Membrane Nanodecoys To Protect Against COVID-19;” U.S. Provisional Patent Application 63/038,380 filed June 12, 2020.
Licensing Contact: Michael Shmilovich, Esq, CLP; 301-435-5019; shmilovm@mail.nih.gov.
Start SignatureDated: June 17, 2020.
Michael A. Shmilovich,
Senior Licensing and Patenting Manager, National Heart, Lung, and Blood Institute, Office of Technology Transfer and Development.
[FR Doc. 2020-13656 Filed 6-24-20; 8:45 am]
BILLING CODE 4140-01-P
Document Information
- Published:
- 06/25/2020
- Department:
- National Institutes of Health
- Entry Type:
- Notice
- Action:
- Notice.
- Document Number:
- 2020-13656
- Pages:
- 38147-38147 (1 pages)
- PDF File:
- 2020-13656.Pdf