[Federal Register Volume 62, Number 133 (Friday, July 11, 1997)]
[Notices]
[Pages 37272-37273]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 97-18141]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program; Call for Public Comments;
Substances, Mixtures and Exposure Circumstances Proposed for Listing in
or Delisting (Removing) From the Report on Carcinogens, Ninth Edition
Background
The National Toxicology Program (NTP) announces its intent to
review additional substances, mixtures and exposure circumstances for
possible listing in or delisting (removing) from the Report on
Carcinogens, Ninth Edition. This Report (previously known as the Annual
Report on Carcinogens) is a Congressionally-mandated listing of known
human carcinogens and reasonably anticipated human carcinogens and its
preparation is delegated to the National Toxicology Program by the
Secretary, Department of Health and Human Services (HHS). Section
301(b)(4) of the Public Health Service Act, as amended, provides that
the Secretary, (HHS), shall publish a report which contains a list of
all substances (1) which either are known to be human carcinogens or
may reasonably be anticipated to be human carcinogens; and (2) to which
a significant number of persons residing in the United States (US) are
exposed. The law also states that the reports should provide available
information on the nature of exposures, the estimated number of persons
exposed and the extent to which the implementation of Federal
regulations decreases the risk to public health from exposure to these
chemicals.
The review of the substances, mixtures or exposure circumstances
for listing in or delisting from the Ninth Report will involve a
multiphased, peer review process involving two Federal scientific
review groups and one non-government, scientific peer review body (a
subcommittee of the NTP Board of Scientific Counselors) which will meet
in an open, public meeting that will provide for public comments. All
available data relevant to the criteria for inclusion or removal of
candidate agents, substances, mixtures or exposure circumstances in the
Report will be evaluated by the three scientific review committees. The
criteria to be used in the review process and the detailed description
of the review procedures, including the steps in the formal review
process, can be obtained by contacting: Dr. C. W. Jameson, National
Toxicology Program, Report on Carcinogens, MD WC-05, P.O. Box 12233,
Research Triangle Park, NC 27709; phone: (919) 541-4096, fax: (919)
541-2242, email: jameson@niehs.nih.gov.
Public Comment Requested
The NTP will be considering 14 substances, mixtures and exposure
circumstances in 1997, for either listing or delisting (removing) from,
or changing the current listing from reasonably anticipated to be a
human carcinogen to the known human carcinogen category in the Ninth
Report. These substances, mixtures or exposure circumstances are
provided in the following table with their Chemical Abstracts Services
(CAS) Registry numbers (where available) and pending review action.
The NTP solicits public input on these 14 substances, mixtures and
exposure circumstances and asks for relevant information anyone may
have on carcinogenesis from completed, ongoing, or planned studies by
others, as well as current production data, use patterns, and human
exposure information for any of the substances, mixtures or exposure
circumstances listed in this announcement. Comments concerning the
review of these substances, mixtures or exposure circumstances for
listing in or delisting from the Ninth Report will be accepted for a
period of 45 days from the date of the publication of this announcement
in the Federal Register. Comments or questions should be directed to
Dr. C. W. Jameson at the address listed above.
Public Nominations for Delisting or Listing Encouraged
The NTP solicits and encourages the broadest participation from
interested individuals or parties in nominating agents, substances, or
mixtures for listing in or delisting from the ninth and future Reports
on Carcinogens. Petitions should contain a rationale for listing or
delisting. Appropriate background information and relevant data (e.g.
Journal articles, NTP Technical Reports, IARC listings, exposure
surveys, release inventories, etc.) which support a petition should be
provided or referenced when possible.
A detailed description of listing/delisting procedures, including
the steps in the formal review process, can be obtained by contacting
Dr. Jameson at the address listed above.
Attachment:
Kenneth Olden,
Director, National Toxicology Program.
Summary for Substances, Mixtures or Exposure Circumstances
Nominated for Consideration of Listing in or Delisting From the
Ninth Report on Carcinogens
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Substance or exposure circumstance/CAS
No. Primary uses or exposures To be reviewed for
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BENZIDINE-BASED DYES AS A CLASS......... Benzidine-based dyes are used primarily Listing in the 9th Report.
for dyeing textiles, paper and leather
products. More than 250 benzidine-based
dyes have been reported by the Society of
Dyers and Colorists.
1,3-BUTADIENE/106-99-0.................. Used primarily as a chemical intermediate Change current listing to
and polymer component in the manufacture the Known to be a Human
of synthetic rubber. Carcinogen category.
CADMIUM and CADMIUM COMPOUNDS/7440-43-9. Used in batteries, coating and plating, Change current listing to
plastic and synthetic products and in the Known to be a Human
alloys. Carcinogen category.
CHLOROPRENE/126-99-8.................... Used as a monomer for neoprene elastomers, Listing in the 9th Report.
industrial rubber products, and as a
component of adhesives in food packaging.
[[Page 37273]]
PHENOLPHTHALEIN/77-09-8................. Used as a laboratory reagent and acid-base Listing in the 9th Report.
indicator and as a cathartic drug in over-
the-counter laxative preparations.
SACCHARIN/218-44-9...................... Used primarily as a nonnutritive Delisting from the Report
sweetening agent. on Carcinogens.
SMOKELESS TOBACCO....................... Oral use of smokeless tobacco products.... Listing in the 9th Report.
SULFURIC ACID MIST/7664-93-9............ Sulfuric acid is the one of the most Listing in the 9th Report.
widely used of all industrial chemicals.
Used in the manufacture of fertilizers,
rayon and other fibers, pigments and
colors, explosives, plastics, coal-tar
products such as dyes and drugs, storage
batteries, synthetic detergents, natural
and synthetic rubber, pulp and paper,
cellophane and catalysts. It is also used
in petroleum refining, pickling iron,
steel and other metals and in ore
concentration.
TAMOXIFEN/10540-29-1.................... Used as an anti-estrogen drug and in the
palliative treatment of.
2,3,7,8-TETRACHLORODIBENZO-............ breast cancer............................. Listing in the 9th Report.
P-DIOXIN (TCDD)/1746-01-6............... Not used commercially, used only as a Change current listing to
research chemical. the Known to be a Human
Carcinogen category.
TETRAFLUOROETHYLENE/116-14-3............ Used in the production of Listing in the 9th Report.
polytetrafluoroethylene (Teflon) and
other polymers. Has also been used as a
propellant for food product aerosols.
TOBACCO SMOKE........................... Inhalation of tobacco smoke............... Listing in the 9th Report.
TRICHLOROETHYLENE/79-01-6............... Used as an industrial solvent for vapor Listing in the 9th Report.
degreasing and cold cleaning of
fabricated metal parts. Has also been
used as a carrier solvent for the active
ingredients of insecticides and
fungicides, as a solvent for waxes, fats,
resins, and oils, as an anesthetic for
medical and dental use, and as an
extractant for spice oleoresins and for
caffeine from coffee.
UV RADIATION............................ Solar and artificial sources of Listing in the 9th Report.
ultraviolet radiation.
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[FR Doc. 97-18141 Filed 7-10-97; 8:45 am]
BILLING CODE 4140-01-P
