[Federal Register Volume 60, Number 134 (Thursday, July 13, 1995)]
[Notices]
[Pages 36152-36153]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 95-17156]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Warren Grant Magnuson Clinical Center: Opportunity for a
Cooperative Research and Development Agreement (CRADA) for the
Scientific and Commercial Development of High Resolution PET Scanner
Using Scintillation Cameras
AGENCY: National Institutes of Health, PHS, DHHS.
ACTION: Notice.
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SUMMARY: The Nuclear Medicine Department in the Clinical Center at the
Warren Grant Magnuson Clinical Center is seeking a collaborator with
expertise in imaging equipment. The primary focus of this collaboration
will be the development and commercialization of an imaging device that
is capable of three distinct types of imaging at high resolution:
Single photon planar imaging, single photon emission computed
tomography (SPECT), and positron emission tomography (PET). An
invention that has set the groundwork for this technology is claimed in
U.S. Patent Applications 08/235,310, entitled ``Variable Axial Aperture
Positron Emission Tomography Scanner'' (filed April 29, 1994) and (CIP)
08/357,574 (filed December 15, 1994). These patents have been filed for
the initial phase of foreign filing (PCT) designating all states. NCI
seeks a collaborator that will apply the technology to develop imagers
for human subjects and/or for high resolution PET imaging of small
animals.
Sponsors will be selected based on their ability to develop and
commercialize the new imaging technology. NCI will enter into CRADA
negotiations with the chosen sponsor with the intention of awarding a
CRADA.
The term of the CRADA(s) is anticipated to be three (3) to five (5)
years.
ADDRESSES: Inquiries and proposals regarding this opportunity should be
addressed to either Michelle Rhyu or Bill Cotreau (Tel # 301-496-0477,
Fax# 301-402-2117), Office of Technology Development, National Cancer
Institute, Building 31, Room 4A49, NIH, 9000 Rockville Pike, Bethesda,
MD 20892.
DATES: Interested parties should notify this office in writing by
September 11, 1995. Respondents will then be given an additional sixty
(60) days for filing a formal proposal.
SUPPLEMENTARY INFORMATION: A Cooperative Research and Development
Agreement (CRADA) is the anticipated joint agreement to be entered into
by NCI pursuant to the Federal Technology Transfer Act of 1986 and
Executive Order 12591 of October 10, 1987. Under the present proposal,
the CRADA will focus on developing the following technology:
An instrument has been devised that utilizes conventional
scintillation cameras to support single photon planar imaging, single
photon emission computed tomography (SPECT), and positron emission
tomography (PET). These multiple capabilities rely on the device's
ability to efficiently detect gamma rays at single photon energies
(<200 kev)="" and="" higher="" positron="" annihilation="" energies="" (511kev)="" required="" for="" pet.="" this="" dual="" ability="" is="" conferred="" by="" pivoting="" the="" detectors="" in="" conventional="" scintillation="" devices,="" which="" are="" capable="" of="" only="" spect="" and="" planar="" imaging,="" thereby="" increasing="" the="" path="" length="" of="" the="" high="" energy="" positron="" in="" the="" detector="" and="" enabling="" its="" detection.="" the="" cameras="" may="" rotate="" about="" a="" fixed="" target,="" or="" stationary="" cameras="" may="" surround="" a="" rotating="" target.="" the="" invention="" makes="" pet="" scanning="" on="" small="" animals="" feasible,="" allowing="" the="" economical="" collection="" of="" test="" data.="" moreover,="" the="" invention="" presents="" a="" promising="" approach="" to="" economically="" increasing="" the="" detection="" capability="" of="" conventional="" spect="" scanners="" for="" humans.="" two="" broad="" advantages="" are="" provided="" by="" the="" present="" invention:="" (1)="" resolution="" of="" pet="" is="" improved="" from="" 6mm="" to="" 2-3mm,="" making="" possible="" the="" resolution="" of="" organs="" in="" small="" animals.="" this="" expands="" the="" usefulness="" of="" small="" animals="" in="" research,="" for="" example="" in="" determining="" how="" test="" tracer="" molecules="" are="" incorporated="" into="" tumors,="" or="" how="" specific="" therapies="" affect="" tumor="" growth.="" the="" invention="" affords="" the="" advantage="" of="" using="" small="" animals,="" which="" are="" easier="" and="" less="" costly="" to="" maintain="" than="" larger="" animals.="" the="" ability="" to="" carry="" out="" pet="" analysis="" on="" smaller="" animals="" also="" circumvents="" the="" need="" to="" dissect="" the="" animal="" in="" order="" to="" assay="" an="" effect,="" greatly="" reducing="" the="" number="" of="" animals="" required="" for="" a="" study.="" (2)="" applying="" this="" technology="" to="" human="" imagers,="" the="" invention="" provides="" a="" cost-effective="" way="" of="" improving="" diagnostic="" capabilities="" for="" [[page="" 36153]]="" a="" relatively="" modest="" expense.="" for="" hospitals="" that="" may="" be="" financially="" prohibited="" from="" operating="" a="" full="" scale="" pet="" imaging="" system="" (including="" onsite="" cyclotron="" and="" radiochemistry="" lab)="" the="" present="" invention="" could="" impart="" pet="" scanning="" capabilities="" to="" the="" lower="" cost="" spect="" instruments,="" reducing="" overall="" cost="" and="" promoting="" widespread="" pet="" use.="" the="" collaboration="" would="" likely="" focus="" on="" demonstration="" of="" concept="" with="" a="" prototype="" system,="" development="" of="" methods="" to="" further="" increase="" coincidence="" detection="" efficiency,="" e.g.,="" use="" of="" 3d="" reconstruction,="" and="" development="" of="" efficient="" methods="" for="" performing="" transmission="" imaging="" and="" other="" required="" corrections.="" background="" patent="" rights="" to="" this="" technology="" are="" available="" for="" licensing="" through="" the="" office="" of="" technology="" transfer,="" nih.="" pertinent="" patent="" application="" claims="" may="" be="" obtained="" under="" a="" nih="" confidentiality="" agreement="" for="" the="" purpose="" of="" reviewing="" patent="" application="" claims.="" for="" this="" and="" further="" licensing="" information="" contact="" mr.="" john="" fahner-="" vihtelic,="" office="" of="" technology="" transfer,="" national="" institutes="" of="" health,="" suite="" 325,="" 6011="" executive="" boulevard,="" rockville,="" maryland="" 20852,="" tel="" (301)="" 496-7057,="" fax="" (301)402-0220.="" party="" contributions="" the="" role="" of="" the="" warren="" grant="" magnuson="" clinical="" center="" includes="" the="" following:="" (1)="" cooperate="" with="" collaborator="" to="" create="" a="" prototype="" spect/pet="" scanning="" device="" following="" the="" above="" described="" specifications;="" advise="" collaborator="" on="" how="" best="" to="" scale="" up="" the="" invention="" into="" a="" prototype="" device.="" (2)="" evaluate="" prototypes="" produced="" by="" collaborator="" using="" small="" animal="" subjects.="" (3)="" provide="" personnel="" and="" laboratory="" space="" for="" these="" studies.="" the="" role="" of="" the="" successful="" corporate="" sponsor(s)="" will="" include:="" (1)="" build="" a="" prototype="" spect/pet="" scanning="" device.="" (2)="" provide="" expertise="" in="" commercial="" scale="" up="" of="" imagers.="" (3)="" provide="" funding="" for="" assistance="" in="" supporting="" the="" research.="" (4)="" provide="" resources="" to="" bring="" product="" to="" market.="" selection="" criteria="" proposals="" submitted="" for="" consideration="" should="" fully="" address="" each="" of="" the="" following="" qualifications:="" (1)="" expertise="" and="" experience="" in="" devising,="" producing="" and="" manufacturing="" imaging="" devices;="" specifically,="" sufficient="" expertise="" to="" collaborate="" on="" development="" of="" a="" spect/pet="" device.="" (2)="" willingness="" to="" produce="" a="" scanner="" optimized="" for="" small="" animal="" studies="" and/or="" a="" scanner="" for="" use="" on="" human="" subjects.="" (3)="" demonstrated="" ability="" to="" market="" invention="" to="" a="" broad="" client="" base.="" (4)="" willingness="" to="" cost="" share="" in="" laboratory="" studies="" including="" the="" funding="" of="" personnel="" dedicated="" to="" completion="" of="" the="" crada="" research="" project.="" (5)="" willingness="" to="" provide="" the="" clinical="" center="" with="" a="" prototype="" spect/pet="" device="" for="" future="" research.="" (6)="" submission="" of="" an="" initial="" response="" to="" the="" nih="" model="" crada="" boilerplate="" provisions.="" (7)="" provisions="" for="" equitable="" distribution="" of="" patent="" rights="" to="" any="" inventions="" generated="" in="" the="" performance="" of="" research="" under="" the="" crada.="" generally,="" the="" rights="" of="" ownership="" are="" retained="" by="" the="" organization="" that="" is="" the="" employer="" of="" the="" inventor,="" with="" (1)="" an="" irrevocable,="" nonexclusive,="" royalty-free="" license="" to="" the="" government="" when="" a="" company="" employee="" is="" the="" sole="" inventor="" or="" (2)="" the="" grant="" of="" an="" option="" to="" negotiate="" for="" an="" exclusive="" or="" a="" nonexclusive="" license="" to="" the="" collaborator="" when="" a="" government="" employee="" is="" the="" sole="" inventor.="" dated:="" may="" 7,="" 1995.="" steven="" m.="" galen,="" technology="" development="" coordinator,="" warren="" grant="" magnuson="" clinical="" center,="" national="" institutes="" of="" health.="" [fr="" doc.="" 95-17156="" filed="" 7-12-95;="" 8:45="" am]="" billing="" code="" 4140-01-p="">