[Federal Register Volume 63, Number 136 (Thursday, July 16, 1998)]
[Notices]
[Pages 38405-38407]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 98-18936]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
Government-Owned Inventions; Availability for Licensing
AGENCY: Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Notice.
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The inventions named in this notice are owned by agencies of the
United States Government and are available for licensing in the United
States (U.S.) in accordance with 35 U.S.C. 207 to achieve expeditious
commercialization of results of federally funded research and
development. Foreign patent applications are filed on selected
inventions to extend market coverage for U.S. companies and may also be
available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to Thomas E.
O'Toole, M.P.H., Licensing and Marketing Specialist, Technology
Transfer Office, Centers for Disease Control and Prevention (CDC),
Mailstop
[[Page 38406]]
E-67, 1600 Clifton Rd., NE., Atlanta, GA 30333, telephone (404) 639-
6270; facsimile (404) 639-6266. A signed Confidential Disclosure
Agreement will be required to receive copies of the patent
applications.
Detection and Identification of Non-polio Enteroviruses
Kilpatrick, David R.
Filed 2 October 96
Serial No. 60/027, 353 (ref# I-001-96)
This invention allows the diagnosis, detection, and differentiation
of clinical paralysis cases due to polioviruses. A new and novel method
for designing polymerase chain reaction (PCR) primes was developed to
differentiate between the three poliovirus serotypes. This method has
been further developed to produce PCR primers capable of
differentiating the 60+ serotypes of nonpolio enterviruses.
Generation of Viral Transfectants Using Recombinant DNA-Derived
Nucleocapsid Proteins
Shaw, Michael W.
Filed 1 May 96
Serial No. 60/017,907 (CDC Ref# I-002-96)
This invention provides a method of producing viral transfectants
that eliminates the need for purified RNP complexes or for purified
viral RNA polymerases. The methods of this invention thus dramatically
simplify the preparation of viral transfectants. The development of
reverse genetics for influenza viruses has allowed the direct
manipulation of virion gene products and the creation of entirely new
recombinant viruses not seen in nature.
Nucleic Acid Assay for the Detection and Differentiation of Three
Chlamydia Species
Messemer, Trudy
Filed 5 September 96
Serial No. 60/025, 509 (Ref# I-006-96)
This invention provides a novel assay for easily and readily
detecting three important Chlamydia sp., i.e., C. trachormatis, C.
psittaci, and C. pneumoniae. These three species may be detected and
differentiated in the same sample aliquot at the same time through the
use of amplification primers targeted to the 16s rRNA gene specific for
each of the species. Additionally, even though multiple targets are
used, the assay described is highly sensitive and specific
consistently.
Inhibitors of Casein Kinase II (Protein Kinase CK2) Inhibit HIV-1
Replication
Critchfield, William
Filed 16 January 98
Serial No. (Ref# I-012-96)
This invention provides compositions and methods which are
effective in inhibiting the activity of specific cellular components
associated with viral replication, specifically protein kinase enzymes
such as casein kinases. These compositions are easily administered by
oral, subcutaneous and intravenous routes, and can be given in dosages
that are safe, and provide inhibition of viral replication. The present
invention provides a method of treating mammalian diseases mediated by
viral infection by administering a composition comprising an anti-viral
compound in a dosage sufficient to inhibit transcription and
translation of viral genomes thereby preventing the propagation of
viral particles.
DNA Polymerase From Treponema Pallidum
Steiner, Bret Martain
Filed 10 June 97
Serial No. 08/872, 094 (Ref# I-013-96)
This invention provides the nucleic acid and amino acid sequences
of the DNA polymerase I region of the Treponema pallidum genome and
sequences of nucleic acid molecules that selectively hybridize with
nucleic acid molecules encoding the DNA polymerase I enzyme from
Treponema pallidum or certain complementary sequences that are
described. The nucleic acid molecules are useful for the production of
recombinant DNA polymerase I enzyme or as probes to detect the presence
of T. pallidum. The nucleic acid and amino acid sequences are also
useful as laboratory research tools to study the organism and the
disease and to develop therapies and treatments for syphilis.
Nucleic Acids for Detection Aspergillus Species
Morrison, Christine
Filed 2 May 97
Serial No. 60/045, 400 (Ref# I-016-96)
The present invention relates to nucleic acids for detecting
Aspergillus species. Unique internal transcribed spacer 2 coding
regions permit the development of probes specific for five different
species, A. flavus, A. fumigatus, A. niger, A. terreus, and A.
nidulans. The invention thereby provides methods for the species-
specific detection and diagnosis of Aspergillus infection in a subject.
Nucleic Acids of the M Antigen Gene of Histoplasma Capsulatum,
Isolated and Recombinantly-Produced Antigens, Vaccine and
Antibodies, Methods and Kits for Detecting Histoplasmosis
Lott, Timothy J.
Filed 30 April 98
Serial No. 60/083,676 CDC Ref# I-002-97
This invention relates to nucleic acids (DNAs) relating to the M
antigen gene of Histoplasma capsulatum; to vectors and host expression
systems containing these nucleic acids; to nucleic acids (RNAs) which
encode the M antigen of H. capsulatum; to isolated and recombinantly-
produced antigens encoded by these nucleic acids; to antibodies
produced against these antigens; to methods and kits for detecting
histoplasmosis using these nucleic acids, antigens and antibodies; and
to vaccines for treatment or prevention of histoplasmosis.
Dust Detector Tube
Volkwein, Jon C
Filed 3 July 97
Serial No. 60/052, 619 (Ref# I-004-97)
The present invention relates to an apparatus for real time dust
dosimetry using the sampling pump having inlet port coupled to the dust
detecting device or tube for detecting dust mass exposure using
differential pressure measurements. The tube is elongated with the
collection filter positioned therein for trapping dust mass. The dust
detecting device coupled to the pump draws the flow of gas there
through and traps selected dust mass at the collection filter.
Differential pressure between the pump side of the collection filter
and the atmosphere is indicative of the cumulative dust mass trapped.
Isocyanate Derivatizing Agent and Methods of Production and Use
Streicher, Robert P.
Filed 13 May 98
Serial No. 60/085,260 (CDC Ref# I-005-97)
This invention relates to a derivatizing agent and method for
detecting and quantifying isocyanate contamination in an environmental
sample. A novel isocyanate derivatizing agent, useful for the
determination of isocyanates in an environmental sample, is provided. A
method for producing this agent and a method for measuring the total
level of isocyanate in an environmental sample are also provided.
Rapid and Sensitive Method for Detecting Histoplasma Capsulatum
Schafer, Millie P.
Filed 21 April 98
Serial No. 60/082,477 (CDC Ref# I-006-97)
This invention relates to detecting a pathogenic fungus,
Histoplasma capsulatum, using oligonucleotide probes specific for H.
capsulatum to
[[Page 38407]]
amplify H. capsulatum DNA by means of the polymerase chain reaction.
Test samples may originate from the environment where H. capsulatum are
found, or from clinical samples obtained from the patients.
New Retrovirus Isolated From Humans
Sandstrom, Paul A.
Filed 3 February 97
Serial No. 08/798, 071 (Ref# I-012-97)
This invention comprises a spumavirus isolate of human origin that
has been definitively isolated from a human with no apparent disease.
This novel spumavirus has been maintained through tissue culture cells
where it causes characteristic vacuolation of the cells. The spumavirus
also has a reagent for the immunological screening of such viruses. The
spumavirus can also serve as a vector in gene therapy because the virus
appears to cause no disease in humans and is not transmitted to other
humans. Additionally, the spumavirus can be used as a reagent in
pathogenicity studies of these and related viruses. Finally, the
sequences of the spumavirus can be used as probes to detect virus in
biological samples.
Hand Wipe Disclosing Method for the Presence of Lead
Esswein, Eric
Filed 11 June 97
Serial No. (Ref# I-014-97)
A method for the detection of lead in surfaces using a handwipe
system and chemical test which includes either rhodizonate or sulfide
ions. This invention is especially useful in detecting the presence of
lead on skin and assessing the effectiveness of hand washing in removal
of lead from the skin of exposed individuals. This invention is also
especially useful in field evaluation for the presence of lead, and the
effectiveness of its subsequent removal.
Epitope Peptides Immunogenic Against Streptococcus Pneumoniae
Carlone, George
Filed 2 March 98
Serial No. 60/076, 565 (Ref# I-017-97)
This invention describes novel immunogenic peptides obtained from a
random library by selection for high affinity binding to monoclonal
antibodies specific for Psa A epitopes. In addition, the peptides of
the invention have the capability if serving as immunogens in a
subject, thereby effectively eliciting the production of antibodies by
the subject and additionally conferring protective immunity against
infection by S. pneumoniae on the subject. The invention also relates
to a selection method employed to obtain such peptides.
Instrumented Cable; Wire for Monitoring Bolts
Martain, Lewis A.
Filed 27 February 98
Serial No. 69/076, 138 (Ref# I-023-97)
This invention provides an apparatus for providing support to a
structure, and for measuring stress placed on the apparatus when
present in the structure. The stress placed upon the apparatus can be
measured at more than one location along the length of the apparatus,
and the apparatus is spinnable into a rock mass without damaging said
stress measuring devices.
Remote Monitoring Safety System
Marshall, Thomas E.
Filed 9 December 97
Serial No. (CDC Ref# I-024-97)
This invention relates to a roof monitoring safety system in which
a single point or multipule points in a single bore hole can be
measured to detect movement or sag in the roof strata of an underground
mine. Movement of the rock strata overlying the mine is measured
directly by use of one or more potentiometers connected via cables to
the rock strata at different locations in a bore hole in the roof
strata.
Method for Developing Degenerate PCR Primers
Kilpatrick, David R.
Filed 15 April 98
Serial No. 60/081,944 (CDC Ref# I-031-97)
The method of this invention provides degenerate primers for the
amplification and subsequent detection of virtually all genes that
encode an amino acid sequence. The degenerate primers are effective for
detection of any gene which lies within a coding region that results in
the production of a protein. Examples of genes that can be detected
include those where the sequence of the specific target gene is
structural, nonstructural, or enzymatic. The method provides highly
specific primers which are effective for substantial amplification of a
target sequence even where the target nucleic acid sequence is unknown.
Oligonucleotide Probes for Detecting Enterbacteriaceae and
Quinolone-Resistant Enterobacteriaceae
Tenover, Fred C.
Filed 1 April 98
Serial No. (Ref# I-003-98)
This invention provides a simple, rapid, and useful method for
differentiating Enterobacteriaceae species and determining their
quinolone-resistance status. This invention also provides material and
methods to apply the species-specific probes to isolated DNA from host
samples for an in vitro diagnosis of Enterobacteiaceae infection.
Method for the Determination of Hexavalent Chromium Using
Ultrasonication and Strong Anion Exchange Solid Phase Extraction
Wang, Jin
Filed 27 February 98
Serial No. 60/076,137 (CDC Ref# I-010-98)
This invention relates to a method for the determination of
hexavalent chromium. Based on the chemical properties of chromium
species in aqueous solutions, a simple, fast, sensitive, and economical
field method has been developed and evaluated for the determination of
hexavalent chromium in environmental and workplace air samples.
Intrinsically-safe Roof Hazard Alert Module
Mayercheck, William D.
Filed 30 April 98
Serial No. 60/083,677 (CDC Ref# I-012-98)
The invention relates to an intrinsically-safe roof hazard warning
device designed to be attached to the roof of a mine to indicate
unsupported roof conditions or other unsafe conditions. The device of
this invention is especially useful in underground mining operations in
order to discourage miners from going into unsupported mine roof areas
by rendering the attendant hazard more evident, directing the miner's
attention to an appropriate warning message on the module, and thus
avoiding the hazard beyond the device. The warning device of this
invention is intrinsically-safe, self-contained, simple to use,
inexpensive to build and operate, portable, light weight, compact, and
low-profile. These features make it useful in short-term or temporary
hazardous situations where the installation of complex or bulky warning
systems may not be warranted or justified.
Dated: July 10, 1998.
Joseph R. Carter,
Acting Associate Director for Management and Operations, Centers for
Disease Control and Prevention (CDC).
[FR Doc. 98-18936 Filed 7-15-98; 8:45 am]
BILLING CODE 4163-18-P
