[Federal Register Volume 61, Number 138 (Wednesday, July 17, 1996)]
[Notices]
[Pages 37279-37280]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-18101]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health; HHS.
ACTION: Notice.
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The inventions listed below are owned by agencies of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for U.S. companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications and issued patents listed below may be obtained by
contacting John Fahner-Vihtelic at the Office of Technology Transfer,
National Institutes of Health, 6011 Executive Boulevard, Suite 325,
Rockville, Maryland 20852-3804; telephone: 301/496-7735 ext 285; fax:
301/402-0220. A signed Confidential Disclosure Agreement will be
required to receive copies of the patent applications.
Broadband Transmit-Receive Switch
TJ Pohida (NCRR)
Filed 06 Nov 95
Serial No. 08/554,003
Transmit-receive (TR) switches are commonly used in complex
electronic systems such as magnetic resonance imaging systems, radar
systems, and a variety of communication systems. These switches are
typically designed using quarter wavelength transmission lines in
conjunction with solid state componentry. Although this type of TR
switch performs well, the desirable properties of a quarter wavelength
transmission lines are only exhibited over about a 10% variation in
frequency. This type of TR switch is considered a narrowband switch. A
significant need exists for a TR switch that uses the advantages of
quarter wavelength impedance transformers and provides a broad
bandwidth. The design of the present invention satisfies those needs by
providing a TR switch which features a broadband frequency response.
This invention can be implemented on any one of several transmission
line media. Also, it can be manufactured according to any known
manufacturing methods for similar devices. This technology has been
implemented on a prototype imaging system. (portfolio: Devices/
Instrumentation--Diagnostics, imaging apparatus)
System and Method for Performing In Vivo Imaging and Oxymetry by Pulsed
Radiofrequency Electron Paramagnetic Resonance
R Murugesan, MK Cherukuri, JB Mitchell, S Subramanian, R Tschudin (NCI)
Filed 20 Jul 95
Serial No. 08/504,616
This invention provides a non-invasive system for in vivo imaging
by fast-response pulsed radiofrequency (RF) electron paramagnetic
resonance (EPR) spectroscopy. The imaging system can be used for
measurement and 3-dimensional imaging of oxygen and free radicals in
living systems, in conjunction with appropriate free radical probes.
The system can be used to perform rapid 3-dimensional mapping of
tissues and vasculature, for example cardiac and cerebral angiography,
and also to distinguish normal and diseased tissues. The short
relaxation time of the probes and the fast response associated with
pulsed EPR techniques permit virtual real-time imaging. The system uses
a magnetic field of only 10 mT-orders or magnitude smaller than the
field used in conventional MRI techniques. The sensitivity, image
resolution, and imaging speed of the pulsed RF EPR system are far
superior to continuous wave RF EPR systems. (portfolio: Devices/
Instrumentation--Diagnostics, imaging apparatus, electron paramagnetic
resonance; Devices/Instrumentation--Diagnostics, imaging apparatus,
spectroscopy)
System and Method for Simulating a Two-Dimensional Radiation Intensity
Distribution of Photon or Electron Beams
J van de Geijn, H Xie (NCI)
Serial No. 08/368,589 filed 06 Jan 95
U.S. Patent No. 5,526,395 issued 11 Jun 96
The present invention provides a method for computer-assisted,
interactive 3-dimensional radiation treatment planning and
optimization. The computerized system is capable of processing and
analyzing data obtained from x-ray, CT, MRI, PET, SPECT, and
gammacamera devices. Hence, the system can be used as a training
device, alleviating the need for training centers to purchase each of
these devices. The computerized system comprises a fast, versatile, and
user-friendly software package and computer components which are
commercially available and which can be used without significant
modification. Because the hardware costs of this system are much lower
than the cost of systems of comparable ability, this invention ought to
be particularly attractive to smaller radiation oncology facilities
which seek a powerful treatment planning system. The low cost of the
system is also particularly advantageous for medical training
facilities, including medical schools. The invention also has potential
use as a monitor for clinical quality assurance. (portfolio: Devices/
Instrumentation--Therapeutics, methods of using devices)
Variable Axial Aperture Positron Emission Tomography Scanner
MV Green, J Seidel, WR Gandler (CC)
Filed 15 Dec 94
Serial No. 08/357,574
Development of a unique system that can operate as both a
scintillation camera and a positron emission tomography (PET) scanner
offers to significantly improve the visualization of physiological
processes in the human body and other biological systems. Single photon
emission computed tomography (SPECT) imaging--which utilizes one or
more scintillation cameras rotated around a subject--is used in nuclear
medicine worldwide. More recently, an alternative to SPECT imaging has
involved the development and use of positron emission tomography (PET)
imaging, in which the subject is surrounded by rings of detectors that
detect the emission of a pair of annihilation photons from positron
emitting racers in the body.
[[Page 37280]]
SPECT and PET imaging, however, require different instrumentation:
scintillation cameras used for SPECT imaging are generally regarded as
too insensitive for effective PET imaging, while PET scanners cannot
effectively image single photon emitting tracers used for SPECT. This
newly developed system attempts to bridge this gap by using two
uncollimated, tiltable scintillation cameras in time coincidence,
rotated about the target to acquire PET image data. Tilting the cameras
in the prescribed manner allows a tradeoff between axial field-of-view
and photon path length through the scintillator that maximizes 2D
coincidence sensitivity compared to cameras in full opposition. The
resulting system exhibits the high spatial resolution expected of a
scintillation camera at 511 keV but with substantially higher
coincidence sensitivity. (portfolio: Devices/Instrumentation--
Diagnostics, imaging apparatus, positron emission tomography)
Enzymatic Degrading Subtraction Hybridization
J Zeng (NCI)
Serial No. 08/322,075 filed 12 Oct 94
U.S. Patent No. 5,525,471 issued 11 Jun 96
The present invention provides an alternative method for selection
and identification of differentially expressed genes involved in
embryonic development and in the onset or maintenance of various
pathological conditions due to genetic alterations in somatic cells.
This method involves the prior modification of tester cDNA which
contains the sequences of interest by incorporation of nuclease
resistant nucleotide analogs. Driver cDNA not containing the sequences
of interest is then used to remove sequences common to driver and
tester cDNA populations through hybridization and subsequent
exonuclease digestion, substantially enriching for the desired
sequences. This method can also be used in conjunction with the phenol-
emulsion reassociation technique (PERT), which significantly
accelerates the hybridization rate allowing, the cDNA molecules to be
efficiently subtracted using a very small amount of DNA. This method is
less expensive, more efficient, and less time-consuming than previous
subtraction hybridization methods. (portfolio: Cancer--Research
Reagents; Cancer--Diagnostics)
Chromatographic Method and Device for Preparing Blood Serum for
Compatibility Testing
R Butz (CC)
Filed 18 Oct 95
DHHS Reference No. E-141-94/0
The present invention provides a new method for antiglobulin
testing of serum from a potential blood transfusion recipient. This
process and device removes warm antibodies from serum to allow for the
identification of alloantibodies present in the sample. The multiple
absorptions required by current methods to remove the warm antibodies
from serum of a potential blood transfusion recipient is superseded by
this invention. The disclosed invention will remove the majority of
warm antibodies in a single one-hour absorption. This invention also
eliminates the need for pretreatment of cells with expensive reagents.
Use of this column and method does not remove any clinically
significant alloantibodies. Therefore, transfusion history accuracy and
subsequent risk to the patient is greatly reduced. (portfolio: Internal
Medicine--Diagnostics, cardiology; Internal Medicine--Miscellaneous)
Dated: July 8, 1996.
Barbara M. McGarey,
Deputy Director, Office of Technology Transfer.
[FR Doc. 96-18101 Filed 7-16-96; 8:45 am]
BILLING CODE 4140-01-M
