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59 FR (07/19/1994) » 94-17746. National Toxicology Program; Availability of Technical Report on Toxicology and Carcinogenesis Studies of p-Nitroaniline
94-17746. National Toxicology Program; Availability of Technical Report on Toxicology and Carcinogenesis Studies of p-Nitroaniline
[Federal Register Volume 59, Number 137 (Tuesday, July 19, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-17746]
[[Page Unknown]]
[Federal Register: July 19, 1994]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Toxicology Program; Availability of Technical Report on
Toxicology and Carcinogenesis Studies of p-Nitroaniline
The HHS' National Toxicology Program announces the availability of
the NTP Technical Report on the toxicology and carcinogenesis studies
of p-nitroaniline, an intermediate in the preparation of several azo
dyes used for coloring consumer products.
Two-year toxicology and carcinogenesis studies were conducted by
administering to both sexes of B6C3F1 mice doses of 0, 3, 30, or
100 mg p-nitroaniline per kg body weight in corn oil by gavage 5 days
per week for up to 103 weeks.
Under the conditions of these 2-year gavage studies, there was
equivocal evidence of carcinogenic activity* of p-nitroaniline in male
B6C3F1 mice based on the increased incidences of hemangiosarcoma
of the liver and hemangioma or hemangiosarcoma (combined) at all sites.
There was no evidence of carcinogenic activity of p-nitroaniline in
female B6C3F1 mice receiving doses of 3, 30, 0r 100 mg/kg.
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*The NTP uses five categories of evidence of carcinogenic
activity observed in each animal study: two categories for positive
results (``clear evidence'' and ``some evidence''), one category for
no observable effect (``no evidence''), and one category for
uncertain findings (``equivocal evidence''), one category for
studies that cannot be evaluated because of major flaws
(``inadequate study'').
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Questions or comments about the Technical Report should be directed
to Central Data Management at P.O. Box 12233, Research Triangle Park,
NC 27709 or telephone (919) 541-3419.
Copies of Toxicology and Carcinogenesis Studies of p-Nitroaniline
(CAS No. 100-01-6) in B6C3F1 Mice (Gavage Studies) (TR-418) are
available without charge from Central Data Management, NIEHS, M.D. AO-
01, P.O. Box 12233, Research Triangle Park, NC 27709; telephone (919)
541-3419.
Dated: July 12, 1994.
Kenneth Olden,
Director, National Toxicology Program.
[FR Doc. 94-17746 Filed 7-18-94; 8:45 am]
BILLING CODE 4140-01-M
Document Information
- Published:
- 07/19/1994
- Department:
- Health and Human Services Department
- Entry Type:
- Uncategorized Document
- Document Number:
- 94-17746
- Pages:
- 0-0 (1 pages)
- Docket Numbers:
- Federal Register: July 19, 1994