Comment submitted by B. Sachau

public comment on federal register of 6/13/07 vol 72 #113 pg 32533 epa 40 cfr part 180 docket 2006 0559 frl 8133-2 attention barbara madden this is a filed objection. the tolerance should be 0.0000. i find the effects of this chemical showing them to be far too dangerous for life on earth. Diuron is a general use pesticide. TOXICOLOGICAL EFFECTS ACUTE TOXICITY Diuron has a low acute toxicity to mammals even though it carries the signal word WARNING on the label. The signal word is applied because the compound can cause eye and throat irritation. It is much less of an irritant to intact skin. The rat oral LD50 ranges from 1017 mg/kg to 3750 mg/kg. Some signs of central nervous system depression have been noted at high levels of diuron exposure. For humans, the only reported case of acute, oral exposure to the herbicide produced no significant symptoms or toxicity. CHRONIC TOXICITY Male rats given extremely high doses of diuron over a two-week period showed changes in their spleen and bone marrow. Other chronic effects attributed to moderate to high doses of the pesticide over time included changes in blood chemistry, increased mortality, growth retardation, abnormal blood pigment, and anemia. When fed small amounts of diuron in food for two years, animal species showed no adverse effects. Reproductive Effects Daily low doses of diuron fed to female rats through three successive generations (pregnancies) caused no effects except on body weight of offspring which significantly decreased in the second and third litters. The fertility rate remained unaffected. Teratogenic Effects Diuron, administered to pregnant rats on days 6 through 15 of gestation, produced no birth defects in the offspring at doses of up to 125 mg/kg. Moderate doses of 250 mg/kg caused wavy ribs, extra ribs and delayed bone formation. There were also weight decreases in offspring at 500 mg/kg. There was no increase in the severity of the rib deformation at this higher dose. Pregnant mice given very high doses of diuron (nearly 2,000 mg/kg) exhibited reproductive and embryotoxic effects. Developmental effects were found in their offspring. you are certainly making it risky for americans to continue to live in good health by the policies of epa who has a risk policy which is far too risky. b.sachau 15 elm st florham park nj07932