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Larry Ladd says regulate. Data gap 1: Chronic effects of ClO4- in the skin. Half-life is longer than in the thyroid or the blood (Yu et al 2002, pubmed id 12140178). No discussion of how ClO4- causes drug-induced lupus and erythema nodosum (Beickert & Heinicke 1968, pmed id 4181403), the role I- sometimes plays in relieving erythema nodosum (Boyd 2007, pmed id 17618179; Sterling & Heymann 2000, pmed id 11004629), or similar ailments caused by chaotropic anions such as iododerma, bromoderma, and bromism. Data gap 2: Variation in infant renal excretion of ClO4-. If pendrin is important in ClO4- as well as I- excretion (for I- see Kim et al -- pmed id 19605545) , expect infant with acidosis (including low HCO3- from chronic diarrhea?) to retain more ClO4- (Frische et al 2003, pmed id 12556366). Data gap 3: Chaotropic effects preventing immuno-coagulation such as opsonization of B-19 parvovirus by IgG (Chehadeh et al 2009, pmed id 19450862, with the parvovirus outbreaks in Dharan after Patriot missile deployment, Badr 2002 pmed 11938419 and western Pennsylvania during peak fireworks production, Beigi 2008, pmed id 18464909 in mind); opsonization of staph by pentraxin 3, which is dependent on a cysteine array (Holland et al, 2009 pmed id 19054079; Inforzato et al 2008, pmed id 18223257); defensin adhesion to coccidoidomycosis, H. pylori, mycobacteria, and influenza, which is also dependent on a cysteine array vulnerable to changes in salinity (Chandrababu et al 2009, pmed 19480463). Analysis is lacking of NIS and SCN- in the airway (Fragoso et al 2004 pmed id 15345749; Pedemonte et al 2007 pmed id 17404297; Wang et al 2006 pmed id 17142773) and nitrosation in the gastrointestinal tract (Suzuki et al 2003 pmed id 12940440). In regards to humoral immunity, you need to evaluate the thickening of rat pup corpus callosum recorded in York et al 2005 (pmed id 16393938) with the migration paths of cd34+ stem cells within the rat brain (Jendelova et al 2005 pmed id 15929552).