§ 558.415 - Novobiocin.

§ 558.415 Novobiocin.

(a) Specifications. Type A medicated article containing 25 grams of novobiocin activity per pound.

(b) Sponsor. See No. 054771 in § 510.600(c) of this chapter.

(c) Related tolerances. See § 556.460 of this chapter.

(d) Conditions of use. It is used in animal feeds as follows:

(1) Chickens -

Novobiocin amount	Indications for use	Limitations	Sponsor
(i)

Amount. Novobiocin, 6-7 mgs. per lb.

To provide 6 to 7 milligrams per pound (mg/lb) of body weight per day.

(a) Indications for use. Aid

Chickens: As an aid in the treatment of breast blisters associated with staphylococcal infections susceptible to novobiocin.

(b) Limitations.

Administer

, as sole ration,

feed which contains not less than 200 grams of novobiocin activity per ton of feed

; not for laying chickens; feed

as the sole ration for 5 to 7 days

; withdraw

. Not for laying chickens. Withdraw 4 days before slaughter.	054771
(ii)

Amount. Novobiocin, 10-14 mgs. per lb.

To provide 10 to 14 mg/lb of body weight per day.

(a) Indications for use. Treatment

Chickens: For the treatment of staphylococcal synovitis and generalized staphylococcal infections susceptible to novobiocin.

(b) Limitations.

Administer

, as sole ration,

feed which contains not less than 350 grams of novobiocin activity per ton of feed

; not for laying chickens; feed

as the sole ration for 5 to 7 days

; withdraw

. Not for laying chickens. Withdraw 4 days before slaughter.

054771

(2) Turkeys -

Novobiocin amount	Indications for use	Limitations	Sponsor
(i)

Amount. Novobiocin, 4-5 mgs. per lb.

To provide 4 to 5 mg/lb of body weight per day.

(a) Indications for use. Aid

Turkeys: As an aid in the treatment of breast blisters associated with staphylococcal infections susceptible to novobiocin.

(b) Limitations.

Administer

, as sole ration,

feed which contains not less than 200 grams of novobiocin activity per ton of feed

; not for laying turkeys; feed

as the sole ration for 5 to 7 days

; withdraw

. Not for laying turkeys. Withdraw 4 days before slaughter.	054771
(ii)

Amount. Novobiocin, 5-8 mgs. per lb.

To provide 5 to 8 mg/lb of body weight per day.

(a) Indications for use. Aid

Turkeys: As an aid in the control of recurring outbreaks of fowl cholera caused by strains of Pasteurella multocida susceptible to novobiocin following initial treatment with 7

-8 mgs. per pound

to 8 mg/lb of body weight per day.

(b) Limitations.

Administer

, as sole ration,

feed which contains not less than 200 grams of novobiocin activity per ton of feed

; feed

as the sole ration for 5 to 7 days

; not

. Not for laying turkeys

; withdraw

. Withdraw 4 days before slaughter.	054771
(iii)

Amount. Novobiocin, 7-8 mgs. per lb.

To provide 7 to 8 mg/lb of body weight per day.

(a) Indications for use. Treatment

Turkeys: For the treatment of staphylococcal synovitis and generalized staphylococcal

infection

infections susceptible to novobiocin; and treatment of acute outbreaks of fowl cholera caused by strains of Pasteurella multocida susceptible to novobiocin.

(b) Limitations.

Administer

, as sole ration,

feed which contains not less than 350 grams of novobiocin activity per ton of feed

; feed

as the sole ration for 5 to 7 days

; not

. Not for laying turkeys

; withdraw

. Withdraw 4 days before slaughter.

054771

(ii) Indications for use. Control

(3) Mink -

(i) Amount. 20 mgs. per lb. body weight per day.

(ii) Indications for use. For treatment of generalized infections, abscesses, or urinary infections caused by staphylococcal or other novobiocin sensitive organisms.

(iii) Limitations. Administer, as sole ration, feed which contains not less than 200 grams of novobiocin activity per ton of feed; feed for 7 days.

(4) Ducks -

(i) Amount. Novobiocin, 350 grams per ton.

Minor species -

Novobiocin amount	Indications for use	Limitations	Sponsor
(i) 350 grams per ton.	Ducks: For the control of infectious serositis and fowl cholera in ducks caused by Pasteurella anatipestifer and P. multocida, susceptible to novobiocin.

(iii) Limitations.

Administer

,

as the sole ration

,

for 5 to 7 days

, continue

. Continue medication for 14 days if necessary

, repeat

. Repeat if reinfection occurs

; discontinue

. Discontinue use at least 3 days before slaughter

; not

. Not for use in laying ducks.	054771
(ii) To provide 20 mg/lb of body weight per day.	Mink: For the treatment of generalized infections, abscesses, or urinary infections caused by staphylococcal or other novobiocin sensitive organisms.	Administer feed which contains not less than 200 grams of novobiocin activity per ton of feed as the sole ration for 7 days.	054771

[40 FR 13959, Mar. 27, 1975, as amended at 45 FR 42263, June 24, 1980; 51 FR 7399, Mar. 3, 1986; 52 FR 36402, Sept. 29, 1987; 79 FR 13545, Mar. 11, 2014; 84 FR 12501, Apr. 2, 2019]