2010-7169. Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

AGENCY:

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

ACTION:

Request for comments on the proposed substances to be evaluated for Set 24 toxicological profiles.

SUMMARY:

This notice announces the list of proposed substances that will be evaluated for Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) Set 24 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public comments on the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the nomination of any additional, substances, not on this list, that may have public health implications.

DATES:

Nominations must be submitted within 30 days of the publication of this notice.

ADDRESSES:

Nominations may be submitted electronically. Refer to the section Submission of Nominations (following) for the specific address.

FOR FURTHER INFORMATION CONTACT:

For further information, contact: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, F-62, Atlanta, GA, 30333; telephone: [phone]; or e-mail: [e-mail].

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601 et seq.] amended the CERCLA (or Superfund) [42 U.S.C. 9601 et seq.] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances most commonly found at facilities on the CERCLA NPL. Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This identifies 275 hazardous substances that ATSDR and EPA have determined pose the most significant potential threat to human health (http://www.atsdr.cdc.gov/​cercla/​07list.html). The availability of the revised list of the 275 priority substances was announced in the Federal Register on March 6, 2008 (73 FR 12178). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); and November 7, 2003 (68 FR 63098), December 7, 2005 (70 FR 72840).

Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles

Each year, ATSDR develops a list of substances to be considered for toxicological profile development. This list is compiled from ATSDR's Priority List of Hazardous Substances and from previously nominated substances of public health concern. The following list of 240 proposed substances will be considered for Set 24 Toxicological Profile development.

	Substances	CAS Nos.
1	METHANE	000074-82-8
2	BROMODICHLOROETHANE	000683-53-4
3	1,2,3-TRICHLOROBENZENE	000087-61-6
4	POLONIUM-210	013981-52-7
5	LEAD-210	014255-04-0
6	NEPTUNIUM-237	013994-20-2
7	S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE	000078-48-8
8	BROMINE	007726-95-6
9	DICOLFOL	000115-32-2
10	PARATHIION	000056-38-2
11	TRICHLOROFLUOROETHANE	027154-33-2
12	TRIFLURALIN	000152-09-8
13	PENTACHLOROBENZENE	000608-93-5
14	TRICHLOROETHANE	025323-89-1
15	PALLADIUM	007440-05-3
16	DIBENZOFURAN	000132-64-9
17	2,4-DIMETHYLPHENOL	000105-67-9
18	TETRACHLOROETHANE	025322-20-7
19	BIS(2-METHOXYETHYL)PHTHALATE	034006-76-3
20	BUTYL BENZYL PHTHALATE	000085-68-7
21	1,2,4-TRICHLOROBENZENE	000120-82-1
22	NITRITE	014797-65-0
23	NITRATE	014797-55-8
24	POTASSIUM-40	013966-00-2
25	THORIUM-227	015623-47-9
26	PHORATE	000298-02-2
27	DIMETHOATE	000060-51-5
28	ACTINIUM-227	014952-40-0
29	STROBANE	008001-50-1
30	4-AMINOBIPHENYL	000092-67-1
31	ARSINE	007784-42-1
32	NALED	000300-76-5
33	ETHOPROP	013194-48-4
34	CARBOPHENOTHION	000786-19-6
35	2,4-D ACID	000094-75-7
36	DIURON	000330-54-1
37	BUTYLATE	002008-41-5
38	DIMETHYL FORMAMIDE	000068-12-2
39	DICHLOROBENZENE	025321-22-6
40	ETHYL ETHER	000060-29-7
41	DICHLOROETHANE	001300-21-6
42	PHOSPHINE	007803-51-2
43	TRICHLOROBENZENE	012002-48-1
44	PENTAERYTHRITOL TETRANITRATE	000078-11-5
45	BIS(2-ETHYLHEXYL)ADIPATE	000103-23-1
46	CARBAZOLE	000086-74-8
47	METHYL ISOBUTYL KETONE	000108-10-1
48	CARBARYL	000063-25-2
49	MERCURY	007439-97-6
50	METHYLMERCURY	022967-92-6
51	MERCURIC CHLORIDE	007487-94-7
52	POLYCHLORINATED BIPHENYLS	001336-36-3
53	AROCLOR 1254	011097-69-1
54	AROCLOR 1260	011096-82-5
55	AROCLOR 1248	012672-29-6
56	AROCLOR 1242	053469-21-9
57	AROCLOR	012767-79-2
58	AROCLOR 1221	011104-28-2
59	AROCLOR 1016	012674-11-2
60	AROCLOR 1232	011141-16-5
61	AROCLOR 1240	071328-89-7
62	TETRACHLOROBIPHENYL	026914-33-0
63	POLYCYCLIC AROMATIC HYDROCARBONS	130498-29-2
64	BENZO(A)PYRENE	000050-32-8
65	BENZO(B)FLUORANTHENE	000205-99-2
66	DIBENZO(A,H)ANTHRACENE	000053-70-3
67	BENZO(A)ANTHRACENE	000056-55-3
68	BENZO(K)FLUORANTHENE	000207-08-9
69	BENZOFLUORANTHENE	056832-73-6
70	FLUORANTHENE	000206-44-0
71	CHRYSENE	000218-01-9
72	ACENAPHTHENE	000083-32-9
73	INDENO(1,2,3-CD)PYRENE	000193-39-5
74	BENZOPYRENE	073467-76-2
75	PHENANTHRENE	000085-01-8
76	PYRENE	000129-00-0
77	FLUORENE	000086-73-7
78	ANTHRACENE	000120-12-7
79	BENZO(A)FLUORANTHENE	000203-33-8
80	BENZO(GHI)PERYLENE	000191-24-2
81	ACENAPHTHYLENE	000208-96-8
82	BENZO(J)FLUORANTHENE	000205-82-3
83	BENZO(E)PYRENE	000192-97-2
84	BENZOPERYLENE	011057-45-7
85	BENZO(B)ANTHRACENE	000092-24-0
86	DIBENZ(A,J)ANTHRACENE	000224-41-9
87	BENZO(GHI)FLUORANTHENE	000203-12-3
88	1-METHYLPYRENE	002381-21-7
89	CHLOROFORM	000067-66-3
90	DDT, P,P′-	000050-29-3
91	DDE, P,P′-	000072-55-9
92	DDD, P,P′-	000072-54-8
93	DDT, O,P′-	000789-02-6
94	DDD, O,P′-	000053-19-0
95	DDE, O,P′-	003424-82-6
96	TRICHLOROETHYLENE	000079-01-6
97	DIELDRIN	000060-57-1
98	ALDRIN	000309-00-2
99	CHLORDANE	000057-74-9
100	CIS-CHLORDANE	005103-71-9
101	TRANS-CHLORDANE	005103-74-2
102	OXYCHLORDANE	027304-13-8
103	GAMMA-CHLORDENE	056641-38-4
104	CHLORDANE, TECHNICAL	012789-03-6
105	ALPHA-CHLORDENE	056534-02-2
106	NONACHLOR, TRANS-	039765-80-5
107	NONACHLOR, CIS-	005103-73-1
108	CHLORDENE	003734-48-3
109	HEXACHLOROBUTADIENE	000087-68-3
110	COAL TAR CREOSOTE	008001-58-9
111	COAL TARS	008007-45-2
112	DDD, P,P′-	000072-54-8
113	COAL TAR PITCH	065996-93-2
114	BENZIDINE	000092-87-5
115	TOXAPHENE	008001-35-2
116	TETRACHLOROETHYLENE	000127-18-4
117	1,2-DIBROMOETHANE	000106-93-4
118	DISULFOTON	000298-04-4
119	3,3′-DICHLOROBENZIDINE	000091-94-1
120	ENDRIN	000072-20-8
121	ENDRIN KETONE	053494-70-5
122	ENDRIN ALDEHYDE	007421-93-4
123	BERYLLIUM	007440-41-7
124	1,2-DIBROMO-3-CHLOROPROPANE	000096-12-8
125	DIBROMOCHLOROPROPANE	067708-83-2
126	PENTACHLOROPHENOL	000087-86-5
127	DI-N-BUTYL PHTHALATE	000084-74-2
128	ENDOSULFAN	000115-29-7
129	ENDOSULFAN SULFATE	001031-07-8
130	ENDOSULFAN, ALPHA	000959-98-8
131	ENDOSULFAN, BETA	033213-65-9
132	METHOXYCHLOR	000072-43-5
133	METHANE	000074-82-8
134	TOLUENE	000108-88-3
135	2-HEXANONE	000591-78-6
136	2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN	001746-01-6
137	HEXACHLORODIBENZO-P-DIOXIN	034465-46-8
138	HEPTACHLORODIBENZO-P-DIOXIN	037871-00-4
139	TETRACHLORODIBENZO-P-DIOXIN	041903-57-5
140	PENTACHLORODIBENZO-P-DIOXIN	036088-22-9
141	1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN	035822-46-9
142	OCTACHLORODIBENZO-P-DIOXIN	003268-87-9
143	1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN	057653-85-7
144	1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN	039227-28-6
145	1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN	019408-74-3
146	1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN	040321-76-4
147	DI(2-ETHYLHEXYL)PHTHALATE	000117-81-7
148	1,1-DICHLOROETHENE	000075-35-4
149	METHYLENE CHLORIDE	000075-09-2
150	BROMODICHLOROETHANE	000683-53-4
151	1,2-DICHLOROETHANE	000107-06-2
152	2,4,6-TRICHLOROPHENOL	000088-06-2
153	TETRACHLOROPHENOL	025167-83-3
154	2,4-DICHLOROPHENOL	000120-83-2
155	2,4,5-TRICHLOROPHENOL	000095-95-4
156	2-CHLOROPHENOL	000095-57-8
157	2,3,4,5-TETRACHLOROPHENOL	004901-51-3
158	2,3,5,6-TETRACHLOROPHENOL	000935-95-5
159	2,3,4,6-TETRACHLOROPHENOL	000058-90-2
160	4-CHLOROPHENOL	000106-48-9
161	CHLOROPHENOL	025167-80-0
162	2,4-DINITROPHENOL	000051-28-5
163	BIS(2-CHLOROETHYL) ETHER	000111-44-4
164	ASBESTOS	001332-21-4
165	CHRYSOTILE ASBESTOS	012001-29-5
166	AMOSITE ASBESTOS	012172-73-5
167	HEXACHLOROBENZENE	000118-74-1
168	2,4-DINITROTOLUENE	000121-14-2
169	DINITROTOLUENE	025321-14-6
170	2,6-DINITROTOLUENE	000606-20-2
171	RADIUM-226	013982-63-3
172	RADIUM	007440-14-4
173	RADIUM-228	015262-20-1
174	RADIUM-224	013233-32-4
175	ETHION	000563-12-2
176	THORIUM	007440-29-1
177	THORIUM-230	014269-63-7
178	THORIUM-228	014274-82-9
179	4,6-DINITRO-O-CRESOL	000534-52-1
180	CHLOROBENZENE	000108-90-7
181	N-NITROSODI-N-PROPYLAMINE	000621-64-7
182	1,2,3-TRICHLOROBENZENE	000087-61-6
183	POLONIUM-210	013981-52-7
184	CHLORPYRIFOS	002921-88-2
185	NEPTUNIUM-237	013994-20-2
186	CHLORDECONE	000143-50-0
187	MIREX	002385-85-5
188	S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE	000078-48-8
189	BROMINE	007726-95-6
190	DICOFOL	000115-32-2
191	PARATHION	000056-38-2
192	SELENIUM	007782-49-2
193	TRICHLOROFLUOROETHANE	027154-33-2
194	TRIFLURALIN	001582-09-8
195	4,4'-METHYLENEBIS(2-CHLOROANILINE)	000101-14-4
196	PENTACHLOROBENZENE	000608-93-5
197	1,1-DICHLOROETHANE	000075-34-3
198	1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN	039001-02-0
199	HEPTACHLORODIBENZOFURAN	038998-75-3
200	2,3,4,7,8-PENTACHLORODIBENZOFURAN	057117-31-4
201	HEXACHLORODIBENZOFURAN	055684-94-1
202	PENTACHLORODIBENZOFURAN	030402-15-4
203	2,3,7,8-TETRACHLORODIBENZOFURAN	051207-31-9
204	DIBENZOFURANS, CHLORINATED	042934-53-2
205	1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN	067562-39-4
206	1,2,3,7,8,9-HEXACHLORODIBENZOFURAN	072918-21-9
207	TETRACHLORODIBENZOFURAN	030402-14-3
208	1,2,3,6,7,8-HEXACHLORODIBENZOFURAN	057117-44-9
209	1,2,3,4,7,8-HEXACHLORODIBENZOFURAN	070648-26-9
210	2,3,4,6,7,8-HEXACHLORODIBENZOFURAN	060851-34-5
211	1,2,3,7,8-PENTACHLORODIBENZOFURAN	057117-41-6
212	1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN	055673-89-7
213	1,1,2-TRICHLOROETHANE	000079-00-5
214	HEXACHLOROCYCLOPENTADIENE	000077-47-4
215	1,2-DIPHENYLHYDRAZINE	000122-66-7
216	1,2-DICHLOROETHENE, TRANS-	000156-60-5
217	1,2-DICHLOROETHYLENE	000540-59-0
218	1,2-DICHLOROETHENE, CIS-	000156-59-2
219	CARBON DISULFIDE	000075-15-0
220	PALLADIUM	007440-05-3
221	CHLOROETHANE	000075-00-3
222	ACETONE	000067-64-1
223	DIBENZOFURAN	000132-64-9
224	2,4-DIMETHYLPHENOL	000105-67-9
225	CHLOROMETHANE	000074-87-3
226	BIS(2-METHOXYETHYL) PHTHALATE	034006-76-3
227	BUTYL BENZYL PHTHALATE	000085-68-7
228	N-NITROSODIMETHYLAMINE	000062-75-9
229	1,2,4-TRICHLOROBENZENE	000120-82-1
230	N-NITROSODIPHENYLAMINE	000086-30-6
231	2-BUTANONE	000078-93-3
232	FLUORINE	007782-41-4
233	HYDROGEN FLUORIDE	007664-39-3
234	FLUORIDE ION	016984-48-8
235	AMMONIA	007664-41-7
236	COPPER	065357-62-2
237	CHLORINE DIOXIDE	010049-04-4
238	PBBs	059536-65-1
239	PBDEs	001163-19-5
240	SYNTHETIC VITREOUS FIBERS	NONE

Submission of Nominations for the Evaluation Set 24 Proposed Substances: Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the nominator, including full name, title, affiliation, e-mail address, and telephone number.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances to be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the Selection Criteria announced in the Federal Register on May 7, 1993 (87 FR 27288).

Submission of Comments: Submit comments via e-mail at: [e-mail]. Please include “Set 24” in the subject line of the e-mail. Or, mail to: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, MS F-62, Atlanta, GA 30333; e-mail: [e-mail].

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time and resources permit.

Dated: March 26, 2010.

Ken Rose,

Associate Director, Office of Policy, Planning and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.