public comment on federal register of 8/11/06 vol 71 #155 pg 46224
georgia wants an emergency use of pyridalyl. i note that many privat eagencies
believe this product has severe health and environment effects. i agree with them
some of them are:
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Pesticides
Adverse Effects
Pyridalyl
CAS No. 179101-81-6
Return to Pyridalyl Index Page
Activity: Iinsecticide (unclassified)
Structure:
Adverse Effects:
Blood
Body Weight Decrease
Endocrine: Adrenal
Endocrine: Ovary
Endocrine: Testes
Kidney
Liver
Lung
Reproductive
Spleen
Environmental - persistence in soil
On December 5, 2003, Valent petitioned US EPA for the first-time tolerances for
residues in food commodities.
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Blood (click on for all fluorinated pesticides)
Subchronic toxicity.
-- Pyridalyl technical was tested in rats in a 3-month feeding study. Effects
included decreased body weight gain, altered blood biochemistry, increased
relative liver weight and histopathological changes in the liver, ovary, adrenal and
lung. The NOAEL is 100 ppm (5.56 mg/kg/day in males and 6.45 mg/kg/day in
females).
-- A 13-week feeding study in mice was conducted. Effects included decreased
body weight gain, hematological and blood biochemical effects,increased liver
weight, decreased kidney and ovary weights and histopathological changes in
liver, kidney, ovary and adrenal. The NOAEL is 70 ppm in males (8.169
mg/kg/day) and 700 ppm in females (86.78 mg/kg/day).
-- A 13-week oral (capsule) toxicity study was conducted in dogs. Effects included
decreased body weight gain, clinical signs indicative of respiratory distress,
hematological and blood biochemistry effects, increased liver, lung and kidney
weights and histopathological alterations of the lung, kidney, adrenal and liver. The
NOAEL was 10 mg/kg/day.
Chronic toxicity.
-- In a 104-week combined chronic/oncogenicity study in rats,
effects included decreased body weight gain, increased frequency of rearing (high
dose females only), hematological alterations and histopathological alterations of
the spleen. No oncogenicity was found. The NOAEL for this study is 100 ppm (3.4
mg/kg/day in males and 4.1 mg/kg/day in females).
-- Pyridalyl was administered for 12-months by capsule to dogs. There were
alterations in blood biochemistry (alkaline phosphatase and alanine
aminotransaminase) and increased liver weights. The NOAEL of the study was 20
mg/kg/day.
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Body Weight Decrease (click on for all fluorinated pesticides)
Subchronic toxicity.
-- Pyridalyl technical was tested in rats in a 3-month feeding study. Effects
included decreased body weight gain, altered blood biochemistry, increased
relative liver weight and histopathological changes in the liver, ovary, adrenal and
lung. The NOAEL is 100 ppm (5.56 mg/kg/day in males and 6.45 mg/kg/day in
females).
-- A 13-week feeding study in mice was conducted. Effects included decreased
body weight gain, hematological and blood biochemical effects,increased liver
weight, decreased kidney and ovary weights and histopathological changes in
liver, kidney, ovary and adrenal. The NOAEL is 70 ppm in males (8.169
mg/kg/day) and 700 ppm in females (86.78 mg/kg/day).
-- A 13-week oral (capsule) toxicity study was conducted in
dogs. Effects included decreased body weight gain, clinical signs indicative of
respiratory distress, hematological and blood biochemistry effects, increased liver,
lung and kidney weights and histopathological alterations of the lung, kidney,
adrenal and liver. The NOAEL was 10 mg/kg/day.
Chronic toxicity.
-- In a 104-week combined chronic/oncogenicity study in rats,
effects included decreased body weight gain, increased frequency of rearing (high
dose females only), hematological alterations and histopathological alterations of
the spleen. No oncogenicity was found. The NOAEL for this study is 100 ppm (3.4
mg/kg/day in males and 4.1 mg/kg/day in females).
-- Pyridalyl was administered in the diet to mice for 78-weeks. Effects included
decreased body weight gain and food consumption/efficiency, and increased liver
and kidney weights. The NOAEL of the study was 50 ppm (5.04 mg/kg/day in
males and 4.78 mg/kg/day in females)
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Endocrine: Adrenal (click on for all fluorinated pesticides)
Subchronic toxicity.
-- Pyridalyl technical was tested in rats in a 3-month feeding study. Effects
included decreased body weight gain, altered blood biochemistry, increased
relative liver weight and histopathological changes in the liver, ovary, adrenal and
lung. The NOAEL is 100 ppm (5.56 mg/kg/day in males and 6.45 mg/kg/day in
females).
-- A 13-week feeding study in mice was conducted. Effects included decreased
body weight gain, hematological and blood biochemical effects,increased liver
weight, decreased kidney and ovary weights and histopathological changes in
liver, kidney, ovary and adrenal. The NOAEL is 70 ppm in males (8.169
mg/kg/day) and 700 ppm in females (86.78 mg/kg/day).
-- A 13-week oral (capsule) toxicity study was conducted in
dogs. Effects included decreased body weight gain, clinical signs indicative of
respiratory distress, hematological and blood biochemistry effects, increased liver,
lung and kidney weights and histopathological alterations of the lung, kidney,
adrenal and liver. The NOAEL was 10 mg/kg/day.
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Endocrine: Ovary (click on for all fluorinated pesticides)
Subchronic toxicity.
-- Pyridalyl technical was tested in rats in a 3-month feeding study. Effects
included decreased body weight gain, altered blood biochemistry, increased
relative liver weight and histopathological changes in the liver, ovary, adrenal and
lung. The NOAEL is 100 ppm (5.56 mg/kg/day in males and 6.45 mg/kg/day in
females).
-- A 13-week feeding study in mice was conducted. Effects included decreased
body weight gain, hematological and blood biochemical effects,increased liver
weight, decreased kidney and ovary weights and histopathological changes in
liver, kidney, ovary and adrenal. The NOAEL is 70 ppm in males (8.169
mg/kg/day) and 700 ppm in females (86.78 mg/kg/day)
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Endocrine: Testes (click on for all fluorinated pesticides)
Possible effect of pyridalyl on the steroid synthesis pathway was surveyed in rats.
It was revealed that pyridalyl affected the sex hormone synthetic pathway in the
testis at the concentration of 3 ?M and higher, and this effect was caused by an
inhibition of testosterone synthesis, via weak but significant inhibition of 17a-HSD
activity. (Ref. 44. Effect of pyridalyl on the sexual hormonal synthetic pathway in
rats: Sumitomo Chemical Co., Ltd., 2002, unpublished.)
Ref: Evaluation Report. PYRIDALYL. January 14, 2004. Japan Food Safety
Commission. Pesticides Expert Committee.
Kidney (click on for all fluorinated pesticides)
Subchronic toxicity.
-- A 13-week feeding study in mice was conducted. Effects included decreased
body weight gain, hematological and blood biochemical effects,increased liver
weight, decreased kidney and ovary weights and histopathological changes in
liver, kidney, ovary and adrenal. The NOAEL is 70 ppm in males (8.169
mg/kg/day) and 700 ppm in females (86.78 mg/kg/day).
-- A 13-week oral (capsule) toxicity study was conducted in
dogs. Effects included decreased body weight gain, clinical signs indicative of
respiratory distress, hematological and blood biochemistry effects, increased liver,
lung and kidney weights and histopathological alterations of the lung, kidney,
adrenal and liver. The NOAEL was 10 mg/kg/day.
Chronic toxicity.
-- Pyridalyl was administered in the diet to mice for 78-weeks. Effects included
decreased body weight gain and food consumption/efficiency, and increased liver
and kidney weights. The NOAEL of the study was 50 ppm (5.04 mg/kg/day in
males and 4.78 mg/kg/day in females)
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Liver (click on for all fluorinated pesticides)
Subchronic toxicity.
-- Pyridalyl technical was tested in rats in a 3-month feeding study. Effects
included decreased body weight gain, altered blood biochemistry, increased
relative liver weight and histopathological changes in the liver, ovary, adrenal and
lung. The NOAEL is 100 ppm (5.56 mg/kg/day in males and 6.45 mg/kg/day in
females).
-- A 13-week feeding study in mice was conducted. Effects included decreased
body weight gain, hematological and blood biochemical effects, increased liver
weight, decreased kidney and ovary weights and histopathological changes in
liver, kidney, ovary and adrenal. The NOAEL is 70 ppm in males (8.169
mg/kg/day) and 700 ppm in females (86.78 mg/kg/day).
-- A 13-week oral (capsule) toxicity study was conducted in
dogs. Effects included decreased body weight gain, clinical signs indicative of
respiratory distress, hematological and blood biochemistry effects, increased liver,
lung and kidney weights and histopathological alterations of the lung, kidney,
adrenal and liver. The NOAEL was 10 mg/kg/day.
Chronic toxicity.
-- Pyridalyl was administered in the diet to mice for 78-weeks. Effects included
decreased body weight gain and food consumption/efficiency, and increased liver
and kidney weights. The NOAEL of the study was 50 ppm (5.04 mg/kg/day in
males and 4.78 mg/kg/day in females)
-- Pyridalyl was administered for 12-months by capsule to
dogs. There were alterations in blood biochemistry (alkaline phosphatase and
alanine aminotransaminase) and increased liver weights. The NOAEL of the study
was 20 mg/kg/day.
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Lung (click on for all fluorinated pesticides)
Subchronic toxicity.
-- Pyridalyl technical was tested in rats in a 3-month feeding study. Effects
included decreased body weight gain, altered blood biochemistry, increased
relative liver weight and histopathological changes in the liver, ovary, adrenal and
lung. The NOAEL is 100 ppm (5.56 mg/kg/day in males and 6.45 mg/kg/day in
females).
-- A 13-week oral (capsule) toxicity study was conducted in
dogs. Effects included decreased body weight gain, clinical signs indicative of
respiratory distress, hematological and blood biochemistry effects, increased liver,
lung and kidney weights and histopathological alterations of the lung, kidney,
adrenal and liver. The NOAEL was 10 mg/kg/day.
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Reproductive (click on for all fluorinated pesticides)
Species Evaluation Test NOAEL Note
Rat Two-generation reproductive toxicity study P Male: 2.80 mg/kg bw/day
P Female: 3.11 mg/kg bw/day
F1 Male: 3.40 mg/kg bw/day
F1 Female: 3.62 mg/kg bw/day
Delayed sexual maturation in females
Ref: Evaluation Report. PYRIDALYL. January 14, 2004. Japan Food Safety
Commission. Pesticides Expert Committee.
Spleen (click on for all fluorinated pesticides)
Chronic toxicity.
-- In a 104-week combined chronic/oncogenicity study in rats,
effects included decreased body weight gain, increased frequency of rearing (high
dose females only), hematological alterations and histopathological alterations of
the spleen. No oncogenicity was found. The NOAEL for this study is 100 ppm (3.4
mg/kg/day in males and 4.1 mg/kg/day in females).
Ref: Federal Register: December 5, 2003. Pyridalyl; Notice of Filing a Pesticide
Petition.
http://www.fluorideaction.org/pesticides/pyridalyl.fr.dec.5.2003.htm
Environmental (click on for all fluorinated pesticides)
The assumed half-life of those regarded as pyridalyl would be 78-361 days, and
those regarded as the sum of pyridalyl and degradation products to be more than
82-361 days. (Ref. 17)
Table 2. The results of residue in soils (Assumed DT50)
Type of test Kind of soil Unchanged compound Total amount of pyridalyl and
two degradates ?
Vessel Volcanic ash clay loam 118 days 270 days
Unsolidified sedimentary rocks clay loam 361 days >361 days
Field Unsolidified sediments clay loam 78 days 82 days
Unsolidified sedimentary rocks clay loam 245 days 255 days
? S-1812-DP: 3,5-dichloro-4- [3-(5-trifluoromethyl-2-pyridyloxy)]- propoxyphenol
? S-1812-DP-Me: 2-[3-(2,6-dichloro-4-methoxyphenoxy)propoxy]-5- (trifluoromethyl)
pyridine
Ref: Evaluation Report. PYRIDALYL. January 14, 2004. Japan Food Safety
Commission. Pesticides Expert Committee.
i personally am sick of mother earth being poisoned by profiteers. we need to find
a more natural way to grow our food. americans already carry far too many toxic
chemicals aroun din their bodies. this is not good for health at all. this agency
allows far to many toxic chemicals to be used. they do not even do combinant
testing. it has been shown that combinant testing of two toxic chemicals can
result in a toxic cocktail two thousand times more toxic.
b. sachau
15 elm st
florham park nj 07932
Comment submitted by b sachau
This is comment on Notice
Pyridalyl; Receipt of Application for Emergency Exemption, Solicitation of Public Comment
View Comment
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